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Uridine triphosphate information


Uridine triphosphate
Skeletal formula of UTP
Ball-and-stick model of the UTP molecule as an anion
Names
IUPAC name
Uridine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
CAS Number
  • 63-39-8 checkY
ChEMBL
  • ChEMBL605653 ☒N
ECHA InfoCard 100.000.508 Edit this at Wikidata
MeSH Uridine+triphosphate
PubChem CID
  • 6133
UNII
  • UT0S826Z60 checkY
CompTox Dashboard (EPA)
  • DTXSID0041147 Edit this at Wikidata
Properties
Chemical formula
C9H15N2O15P3
Molar mass 484.141
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5′ position. Its main role is as substrate for the synthesis of RNA during transcription. UTP is the precursor for the production of CTP via CTP synthetase.[1] UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using the phosphate group from ATP.[2][3] UDP + ATP ⇌ UTP + ADP;[4] both UTP and ATP are energetically equal.[4]

The homologue in DNA is thymidine triphosphate (TTP or dTTP). UTP also has a deoxyribose form (dUTP).

  1. ^ Meisenberg, Gerhard Meisenberg (2017). Principles of Medical Biochemistry. Philadelphia, PA, USA: Elsevier. p. 505. ISBN 978-0-323-29616-8.
  2. ^ Victor, Rodwell (2015). Haper's illustrated Biochemistry. USA: McGraw-Hill. p. 118. ISBN 978-0-07-182537-5.
  3. ^ Meisenberg, Gerhard Meisenberg (2017). Principles of MEDICAL BIOCHEMISTRY, 4th edition. Philadelphia, PA, USA: Elsevier. p. 59. ISBN 978-0-323-29616-8.
  4. ^ a b Voet, Donald (2011). Biochemistry, 4th edition. USA: JOHN WILEY & SONS, INC. p. 645. ISBN 978-0-470-57095-1.

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Uridine triphosphate

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Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ carbon of the ribose sugar...

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Nucleotide

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nucleoside triphosphates, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP), and uridine triphosphate (UTP)—throughout...

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Thymidine triphosphate

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its name. The corresponding ribonucleoside triphosphate is called uridine triphosphate. It can be used by DNA ligase to create overlapping "sticky ends"...

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Uridine diphosphate

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pyrophosphorylase forms a UDP-glucose unit by combining glucose 1-phosphate with uridine triphosphate, cleaving a pyrophosphate ion in the process. Then, the enzyme glycogen...

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Uridine

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Uridine (symbol U or Urd) is a glycosylated pyrimidine analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a...

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Nucleic acid metabolism

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synthesizing uridine-monophosphate, it can react with 2 ATP to form uridine-triphosphate or UTP. UTP can be converted to CTP (cytidine-triphosphate) in a reaction...

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Nucleotide salvage

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can phosphorylate UMP into uridine diphosphate, which nucleoside diphosphate kinase can phosphorylate into uridine triphosphate. Thymidine phosphorylase...

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P2Y receptor

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stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate and UDP-glucose.To date, 8 P2Y...

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Guanosine triphosphate

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Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription...

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CTP synthase 1

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synthesis pathway that catalyses the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP). CTP is a key building block for the production...

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Glycogen

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requires the input of energy. Energy for glycogen synthesis comes from uridine triphosphate (UTP), which reacts with glucose-1-phosphate, forming UDP-glucose...

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Peptidoglycan

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N-acetyl-glucosamine-1-phosphate, which is now a monophosphate, attacks UTP. Uridine triphosphate, which is a pyrimidine nucleotide, has the ability to act as an energy...

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Cytidine monophosphate

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adenosine triphosphate or guanosine triphosphate donating the phosphate group. Since cytidine triphosphate is generated by amination of uridine triphosphate, the...

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Glycogen branching enzyme

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during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become UDP-glucose, an activated form of glucose. The activated...

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UTP

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Look up UTP in Wiktionary, the free dictionary. UTP may refer to: Uridine triphosphate, in biochemistry Untripentium, a hypothetical chemical element Unifying...

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Uracil

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the body. Uracil becomes uridine, uridine monophosphate (UMP), uridine diphosphate (UDP), uridine triphosphate (UTP), and uridine diphosphate glucose (UDP-glucose)...

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CAD protein

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uses glutamine, carbon dioxide and ATP. This enzyme is inhibited by uridine triphosphate (feedback inhibition). In 2015, the first observed pathological mutations...

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Aminoallyl nucleotide

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and number of phosphates are indicated (i.e. aa-UTP = aminoallyl uridine triphosphate). The goal of combining fluorescence and nucleic acids has been to...

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DNA microarray

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the coupling stage occurs before hybridization, using aminoallyl uridine triphosphate (aminoallyl-UTP, or aaUTP) and NHS amino-reactive dyes (such as cyanine...

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Purinergic signalling

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breakdown product adenosine. The signalling effects of uridine triphosphate (UTP) and uridine diphosphate (UDP) are generally comparable to those of ATP...

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RNA world

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cell: adenosine triphosphate is used everywhere in preference to guanosine triphosphate, cytidine triphosphate, uridine triphosphate or even deoxythymidine...

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Cytidine triphosphate

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Cytidine triphosphate (CTP) is a pyrimidine nucleoside triphosphate. CTP, much like ATP, consists of a ribose sugar, and three phosphate groups. The major...

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Uridine monophosphate

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Uridine monophosphate (UMP), also known as 5′-uridylic acid (conjugate base uridylate), is a nucleotide that is used as a monomer in RNA. It is an ester...

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Galactosamine

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to UDP-galactosamine accumulation within cells, and uridine triphosphate (UTP), UDP, and uridine monophosphate (UMP) decrease. The depletion of high-energy...

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Tumor metabolome

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synthesis, a low ratio of Adenosine triphosphate and Guanosine triphosphate to Cytidine triphosphate and Uridine triphosphate, low Adenosine monophosphate levels...

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Carbamoyl phosphate synthase II

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phosphate It is activated by ATP and PRPP and it is inhibited by UTP (Uridine triphosphate) Neither CPSI nor CPSII require biotin as a coenzyme, as seen with...

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Transferase

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"Uridyl transferases and the formation of uridine triphosphate; enzymic production of uridine triphosphate: uridine diphosphoglucose pyrophosphorolysis"....

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Tunicamycin

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position. The other starter unit for tunicamycin is uridine, which is produced from uridine triphosphate (UTP). TunN is a nucleotide diphosphatase, and catalyzes...

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