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Uracil dehydrogenase information


Uracil dehydrogenase
Identifiers
EC no.1.1.99.19
CAS no.9029-00-9
Databases
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BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Uracil dehydrogenase (EC 1.1.99.19, uracil oxidase) is an enzyme with systematic name uracil:(acceptor) oxidoreductase.[1] This enzyme catalyses the following chemical reaction

uracil + acceptor barbiturate + reduced acceptor

Also oxidizes thymine. The enzyme acts on the hydrated derivative of the substrate.

  1. ^ Hayaishi O, Kornberg A (May 1952). "Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes". The Journal of Biological Chemistry. 197 (2): 717–32. PMID 12981104.

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Uracil dehydrogenase

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Uracil dehydrogenase (EC 1.1.99.19, uracil oxidase) is an enzyme with systematic name uracil:(acceptor) oxidoreductase. This enzyme catalyses the following...

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Dihydropyrimidine dehydrogenase deficiency

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significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine. Individuals with this condition...

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Fluorouracil

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stomatitis through use of allopurinol mouthwash. The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines...

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Orotic acid

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Thomas B (1986). "The structures of tetraaqua(uracil-6-carboxylate)zinc(II) monohydrate (A) and tetraaqua(uracil-6-carboxylato)nickel(II) monohydrate (B)"...

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Tegafur

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agents achieve this by inhibiting the enzyme dihydropyrimidine dehydrogenase (uracil/gimeracil) or orotate phosphoribosyltransferase (oteracil). The...

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Dihydrouracil

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intermediate in the catabolism of uracil. It is the base present in the nucleoside dihydrouridine. Dihydrouracil dehydrogenase (NAD+) Dihydrouracil oxidase...

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Guanine

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nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA). In DNA, guanine is paired with cytosine. The guanine nucleoside...

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Citric acid cycle

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all dehydrogenases in the citric acid cycle with the exception of succinate dehydrogenase, inhibits pyruvate dehydrogenase, isocitrate dehydrogenase, α-ketoglutarate...

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Index of molecular biology articles

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activator sequence - upstream DNA - upstream (transduction) - uracil - uracil/thymine dehydrogenase - ureidoglycolate hydrolase - VAMAS6 - vanillin synthase...

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Biosynthesis

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linked to the ribose sugar via a glycosidic bond are thymine, cytosine and uracil (which is only found in RNA). Uridine monophosphate biosynthesis involves...

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Sarcosine dehydrogenase

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sarcosine dehydrogenase also seems to play a role in the progression process of prostate cancer. The concentration of sarcosine, along with those of uracil, kynurenine...

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List of enzymes

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numbering system: Dehydrogenase Luciferase DMSO reductase Category:EC 1.1.1 (with NAD+ or NADP+ as acceptor) Alcohol dehydrogenase (NAD) EC 1.1.1.1 Alcohol...

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Nucleic acid metabolism

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and excreted or can be salvaged as nucleotide components. Cytosine and uracil are converted into beta-alanine and later to malonyl-CoA which is needed...

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Inosine

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converted into inosine (I), which pairs with adenine (A), cytosine (C), and uracil (U).[citation needed] Purine nucleoside phosphorylase intraconverts inosine...

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UPB1

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pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase...

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Outline of biochemistry

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mRNA – tRNA – rRNA – codon – adenosine – cytosine – guanine – thymine – uracil Proteins : amino acid – glycine – arginine – lysine peptide – primary structure...

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Pyrimidine metabolism

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catabolized (degraded) to CO2, H2O, and urea. Cytosine can be broken down to uracil, which can be further broken down to N-carbamoyl-β-alanine, and then to...

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Ribonucleotide

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bases for ribonucleotides are adenine (A), guanine (G), cytosine (C), or uracil (U). The nitrogenous bases are classified into two parent compounds, purine...

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Uric acid

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hypoxanthine. XO, which is found in mammals, functions primarily as a dehydrogenase and rarely as an oxidase, despite its name.) Xanthine in turn is produced...

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RNA world

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DNA—adenine, guanine, cytosine and uracil, instead of adenine, guanine, cytosine and thymine. Chemically, uracil is similar to thymine, differing only...

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Purine metabolism

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Bifunctional purine biosynthesis protein PURH, encoded by the ATIC gene. IMP dehydrogenase (IMPDH) converts IMP into XMP GMP synthase converts XMP into GMP GMP...

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Morpheein

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"Different Oligomeric States are Involved in the Allosteric Behavior of Uracil Phosphoribosyltransferase from Escherichia Coli". European Journal of Biochemistry...

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Outline of biology

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helix Nucleobase: adenine (A) – cytosine (C) – guanine (G) – thymine (T) – uracil (U) DNA replication – mutation – mutation rate – proofreading – DNA mismatch...

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Enterobacteriaceae

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phosphoglucosamine mutase, glycosyl hydrolase 1 family protein, 23S rrna [uracil(1939)-C(5)]-methyltransferase, co-chaperone HscB, N-acetylmuramoyl-L-alanine...

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