USP7 information

USP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NB8, 1NBF, 1YY6, 1YZE, 2F1W, 2F1X, 2F1Y, 2F1Z, 2FOJ, 2FOO, 2FOP, 2KVR, 2XXN, 2YLM, 3MQR, 3MQS, 4JJQ, 4KG9, 4M5W, 4M5X, 4PYZ, 4WPH, 4WPI, 4YOC, 5C56, 5C6D, 4YSI, 5FWI
Identifiers
Aliases	USP7, HAUSP, TEF1, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific peptidase 7, HAFOUS
External IDs	OMIM: 602519; MGI: 2182061; HomoloGene: 2592; GeneCards: USP7; OMA:USP7 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	8,975,328 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	8,610,172 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; Achilles tendon; ; epithelium of colon; ; ventricular zone; ; rectum; ; skin of leg; ; skin of abdomen; ; secondary oocyte; ; ganglionic eminence;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; ureter; ; fetal liver hematopoietic progenitor cell; ; primary oocyte; ; Paneth cell; ; human fetus; ; mesenteric lymph nodes; ; substantia nigra; ; secondary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; p53 binding; transcription factor binding; peptidase activity; protein C-terminus binding; protein binding; thiol-dependent deubiquitinase; cysteine-type endopeptidase activity; hydrolase activity; ubiquitin protein ligase binding; deubiquitinase activity; Lys48-specific deubiquitinase activity;
Cellular component	cytoplasm; PML body; nuclear body; nucleoplasm; nucleus; cytosol; chromosome; protein-containing complex;
Biological process	maintenance of DNA methylation; ubiquitin-dependent protein catabolic process; protein stabilization; proteolysis; cellular response to DNA damage stimulus; multicellular organism development; regulation of DNA-binding transcription factor activity; regulation of telomere capping; transcription-coupled nucleotide-excision repair; viral process; negative regulation of NF-kappaB transcription factor activity; DNA repair; protein ubiquitination; protein deubiquitination; monoubiquitinated protein deubiquitination; histone H2B conserved C-terminal lysine deubiquitination; regulation of protein stability; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked deubiquitination; positive regulation of DNA demethylation; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	7874
	252870
	ENSG00000187555
	ENSMUSG00000022710
	Q93009
	Q6A4J8
	NM_003470; NM_001286457; NM_001286458; NM_001321858
	NM_001003918
	NP_001273386; NP_001273387; NP_001308787; NP_003461
	NP_001003918
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187555 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022710 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
^ Robinson PA, Lomonte P, Markham AF, Everett RD (Mar 1999). "Assignment1 of herpesvirus-associated ubiquitin-specific protease gene HAUSP to human chromosome band 16p13.3 by in situ hybridization". Cytogenetics and Cell Genetics. 83 (1–2): 100. doi:10.1159/000015142. PMID 9925944. S2CID 34084848.
^ "Entrez Gene: USP7 ubiquitin specific peptidase 7 (herpes virus-associated)".
^ Everett RD, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J (Apr 1997). "A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein". The EMBO Journal. 16 (7): 1519–30. doi:10.1093/emboj/16.7.1519. PMC 1169756. PMID 9130697.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187555 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022710 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[pmid9925944-6] Robinson PA, Lomonte P, Markham AF, Everett RD (Mar 1999). "Assignment1 of herpesvirus-associated ubiquitin-specific protease gene HAUSP to human chromosome band 16p13.3 by in situ hybridization". Cytogenetics and Cell Genetics. 83 (1–2): 100. doi:10.1159/000015142. PMID 9925944. S2CID 34084848.

[entrez-7] "Entrez Gene: USP7 ubiquitin specific peptidase 7 (herpes virus-associated)".

[pmid9130697-8] Everett RD, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J (Apr 1997). "A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein". The EMBO Journal. 16 (7): 1519–30. doi:10.1093/emboj/16.7.1519. PMC 1169756. PMID 9130697.

USP7 information

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