Type of molecule that may be able to induce death of senescent cells
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A senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans.[1] A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases.[2][3] Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.[4]
A related concept is "senostatic", which means to suppress senescence.[5]
^Childs BG, Durik M, Baker DJ, van Deursen JM (December 2015). "Cellular senescence in aging and age-related disease: from mechanisms to therapy". Nature Medicine. 21 (12): 1424–1435. doi:10.1038/nm.4000. PMC 4748967. PMID 26646499.
^Kirkland JL, Tchkonia T (August 2015). "Clinical strategies and animal models for developing senolytic agents". Experimental Gerontology. 68: 19–25. doi:10.1016/j.exger.2014.10.012. PMC 4412760. PMID 25446976.
^van Deursen JM (May 2019). "Senolytic therapies for healthy longevity". Science. 364 (6441): 636–637. Bibcode:2019Sci...364..636V. doi:10.1126/science.aaw1299. PMC 6816502. PMID 31097655.
^Chambers ES, Akbar AN (2020). "Can blocking inflammation enhance immunity during aging?". The Journal of Allergy and Clinical Immunology. 145 (5): 1323–1331. doi:10.1016/j.jaci.2020.03.016. PMID 32386656.
^Hu, Qinchao; Peng, Jianmin; Jiang, Laibo; Li, Wuguo; Su, Qiao; Zhang, Jiayu; Li, Huan; Song, Ming; Cheng, Bin; Xia, Juan; Wu, Tong (28 October 2020). "Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma". Cell Death & Disease. 11 (10): 925. doi:10.1038/s41419-020-03126-0. PMC 7595194. PMID 33116117.
A senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively...
diabetes and atherosclerosis. This has motivated researchers to develop senolytic drugs to kill and eliminate senescent cells to improve health in the elderly...
further research is needed. Fisetin has been shown to be an effective senolytic agent in wild-type mice, with effects of increased lifespan, reduced senescence...
treatment of cardiac arrhythmias. Cardiac glycosides were identified as senolytics: they can selectively eliminate senescent cells which are more sensitive...
tackle the 'ageing problem' using therapy. In 2015 a new class of drugs senolytics was announced (currently in pre-clinical development) designed specifically...
senescence. The polyphenol quercetin has been found to be an effective senolytic for inducing the death of senescent HUVECs. Park HJ, Zhang Y, Georgescu...
learning model is trained to recognise the key features of chemicals with senolytic activity. It finds three chemicals – ginkgetin, periplocin and oleandrin...
senescence. Approaches being explored include fasting, exercise, and senolytic drugs. Forecasting life expectancy and mortality form an important subdivision...
cause, a belief which is supported by benefits seen in patients given senolytic therapy. It is hypothesized that the initial or repetitive injury in IPF...
jellyfish do not die of old age and exhibit potential immortality. A senolytic (from the words senescence and -lytic, "destroying") is among a class...
Dasatinib is a Src tyrosine kinase inhibitor that is effective both as a senolytic and as therapy for CML. Sunitinib, an inhibitor of the receptors for FGF...
trimers in good yields. Procyanidin C1 has been shown to be an effective senolytic agent in wild-type mice, with effects of increased lifespan, reduced senescence...
Acosta, Juan Carlos; Oyarzún, Diego A. (27 April 2022). "Discovery of new senolytics using machine learning". doi:10.1101/2022.04.26.489505. hdl:10261/269843...
"Dasanix". Medex. Retrieved 19 May 2021. Kirkland JL, Tchkonia T (2020). "Senolytic drugs: from discovery to translation". Journal of Internal Medicine. 288...
dose-limiting.[citation needed] In animal studies, navitoclax was found to be a senolytic agent, inducing apoptosis in senescent, but not non-senescent cells. Oral...
IL-1α blockers Mitochondrial depleters in the case of impaired mitophagy Senolytics – small molecules that specifically induce cell death in senescent cells...
Longevity Fund investments include Unity Biotechnology, which develops senolytic drugs targeting diseases of aging, Navitor Pharmaceuticals, and Metacrine...
behind aging". Japan Times. 12 December 2021. Retrieved 12 December 2021. "Senolytic vaccination improves normal and pathological age-related phenotypes and...
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