Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it is also the most abundant protein type found in all vertebrates. Type I forms large, eosinophilic fibers known as collagen fibers, which make up most of the rope-like dense connective tissue in the body.[1] Collagen I itself is created by the combination of both a proalpha1 and a proalpha2 chain created by the COL1alpha1 and COL1alpha2 genes respectively. The Col I gene itself takes up a triple-helical conformation due to its Glycine-X-Y structure, x and y being any type of amino acid. Collagen can also be found in two different isoforms, either as a homotrimer or a heterotrimer, both of which can be found during different periods of development. Heterotrimers, in particular, play an important role in wound healing,[2] and are the dominant isoform found in the body.[2]
Type I collagen can be found in a myriad of different places in the body, mainly forming the matrix of connective tissues. It is present in scar tissue as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin, and organ capsules.
^"Collagen: What It Is, Types, Function & Benefits". Cleveland Clinic. Retrieved 2023-10-25.
^ abElena Makareeva (2014). "Collagen Structure, Folding and Function". Osteogenesis Imperfecta a Translational Approach to Brittle Bone Disease: 71–84. doi:10.1016/B978-0-12-397165-4.00007-1. ISBN 9780123971654.
TypeIcollagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it...
to determine the scientific impact of Type II collagen supplements on skin health. TypeIcollagenCollagen, type III, alpha 1 Park KS, Park MJ, Cho ML...
containing typeIcollagen. Type V collagen is a part of the family of collagen proteins consisting of CollagenI- Collagen XXVIII. Collagen proteins are...
Over 90% of the collagen in the human body is typeIcollagen. However, as of 2011, 28 types of human collagen have been identified, described, and divided...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational...
biology, the collagen triple helix or type-2 helix is the main secondary structure of various types of fibrous collagen, including typeIcollagen. In 1954...
problem with connective tissue due to a lack of, or poorly formed, typeIcollagen.: 1513 In more than 90% of cases, OI occurs due to mutations in the...
defects in collagen-encoding genes. The collagen can be divided into several families according to the types of structure they form: Fibrillar (TypeI, II,...
a type of connective tissue with fibers as its main matrix element. The fibers are mainly composed of typeIcollagen. Crowded between the collagen fibers...
elasticity to the latter. It is the only type of cartilage that contains typeIcollagen in addition to the normal type II. The extracellular matrix of fibrocartilage...
growth and repair of cartilage. Perichondrium contains type I collagen and type XII collagen. Michael H. Ross. Histology: A Text and Atlas, with Correlated...
corpus luteum is being broken down by macrophages, fibroblasts lay down typeIcollagen, forming the corpus albicans. This process is called "luteolysis"....
composed of connective tissue. Most types of connective tissue consists of three main components: elastic and collagen fibers, ground substance, and cells...
is composed of fibers and ground substance. The predominant type of fiber is typeIcollagen and comprises ninety percent of the osteoid. The ground substance...
produces collagen fibrils. In the body, collagen fibrils are composed of several types of collagen as well as macromolecules. TypeIcollagen is the most...
three different macromolecules. Type II Collagen is an example of homotrimeric protein, while TypeIcollagen is an AAB-type heterotrimeric protein. Porins...
granulation tissue are removed by apoptosis, and type III collagen is largely replaced by typeI. Collagen which was originally disorganized is cross-linked...
an organic matrix of collagentype-I. Collagentype-I molecules form a composite material with hydroxyapatite to make up collagen fibrils. The hierarchal...
defect in the synthesis of collagen (TypeI or III) and cause progressive deterioration of collagen, with different EDS types affecting different sites...
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