Global InformationType V collagen information
Type V collagen is a form of fibrillar[1] collagen associated with classical Ehlers-Danlos syndrome. It is found within the dermal/epidermal junction, placental tissues, as well as in association with tissues containing type I collagen.[2]
Type V collagen is a part of the family of collagen proteins consisting of Collagen I- Collagen XXVIII. Collagen proteins are often associated with the strengthening and support of many tissues including skin, bones, muscles, and ligaments. There are some studies that suggest that Type V collagen is responsible for the formation of other collagen fibrils in different tissues within the body.[3] According to studies, Collagen V regulates the heterotypic fiber diameter.[4] Type V Collagen is considered a regulatory fibril forming collagen.[5] Collagen V is associated with the COL5A1 gene which is the gene which provides instructions to produce Collagen V. Type V Collagen, like other collagens, is made up of procollagen molecules.
Collagen V molecular isoforms are α1(V)α2(V)α3(V), α1(V)3, and α1(V)2 α2(V). These procollagen molecules are made up of three different α -polypeptide chains.[5] These α -polypeptide chains are α1(V), α2(V), and α3(V). Different combinations of these chains form the Type V collagen Isoforms. Procollagen molecules then form mature collagen with the help of enzymes. After the chains are formed, they arrange into thin fibrils. These collagen fibrils then assort with type I collagen fibrils.[3]
Type V collagen is a part of the Extracellular Matrix (ECM).[5] Collagen V is gene expression modulated by TGF-β. Type V collagen has shown that it is resistant to digestion by interstitial collagenases. Denatured collagen V on the other hand, can be degraded by gelatinases as well as metalloproteinases.[5]
- ^ Wenstrup RJ, Florer JB, Brunskill EW, Bell SM, Chervoneva I, Birk DE (December 2004). "Type V collagen controls the initiation of collagen fibril assembly". The Journal of Biological Chemistry. 279 (51): 53331–53337. doi:10.1074/jbc.M409622200. PMID 15383546.
- ^ Malfait F, Wenstrup R, De Paepe A (1993). Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Amemiya A (eds.). "Ehlers-Danlos Syndrome, Classic Type". GeneReviews. Seattle (WA): University of Washington, Seattle. PMID 20301422.
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