Macromolecular complex formed by three macromolecules
Assembled human PCNA (PDB 1AXC), a sliding DNA clamp protein that is part of the DNA replication complex and serves as a processivity factor for DNA polymerase. The three individual polypeptide chains that make up the trimer are shown.
In biochemistry, a protein trimer is a macromolecular complex formed by three, usually non-covalently bound, macromolecules like proteins or nucleic acids. A protein trimer often occurs from the assembly of a protein's quaternary structure.[1] The non-covalent interactions between the hydrophobic and hydrophilic regions on the polypeptides units help to stabilize the quaternary structure. Since a protein trimer is composed of multiple polypeptide subunits, it is considered an oligomer.[2]
A homotrimer would be formed by three identical molecules. A heterotrimer would be formed by three different macromolecules. Type II Collagen is an example of homotrimeric protein, while Type I collagen is an AAB-type heterotrimeric protein.
Porins usually arrange themselves in membranes as trimers.
^Godbey, W.T. (2014), "Proteins", An Introduction to Biotechnology, Elsevier, pp. 9–33, doi:10.1016/b978-1-907568-28-2.00002-2, ISBN 978-1-907568-28-2, retrieved 2024-05-03
^Pelley, John W. (2012-01-01), Pelley, John W. (ed.), "3 - Protein Structure and Function", Elsevier's Integrated Review Biochemistry (Second Edition), Philadelphia: W.B. Saunders, pp. 19–28, doi:10.1016/b978-0-323-07446-9.00003-9, ISBN 978-0-323-07446-9, retrieved 2024-05-03
a proteintrimer is a macromolecular complex formed by three, usually non-covalently bound, macromolecules like proteins or nucleic acids. A protein trimer...
trimer in Wiktionary, the free dictionary. Trimer may refer to: Trimer (chemistry), a reaction product composed of three identical molecules Protein trimer...
containing two zinc ions and a magnesium ion.[8] Dimer (chemistry) Proteintrimer Oligomer ProtCID Sluis-Cremer N, Hamamouch N, San Félix A, Velazquez...
"dimer of dimers". Hexamers of 32 point group symmetry are "trimer of dimers" or "dimer of trimers". Thus, the nomenclature "dimer of dimers" is used to specify...
of the protein interact through their ectodomains. The trimer structures have been described as club- pear-, or petal-shaped. Each spike protein contains...
command to trim whitespace from the ends of text Transport of ions in matter, a computer program Tripartite motif family, a protein family Trim, adjustment...
surface of an enveloped virus.: 29–33 The proteins are usually glycoproteins that form dimers or trimers.: 29–33 The term "peplomer" refers to an individual...
Technology of the UK government Craniosacral therapy CST complex, a proteintrimer Cambridge Systems Technology, Former UK computing company Centistokes...
by a receptor, Gα is bound to GDP and to Gβγ to form the inactive G proteintrimer. When the receptor binds an activating ligand outside the cell (such...
bound to guanosine diphosphate (GDP) and to Gβγ to form the inactive G proteintrimer. When the receptor binds an activating ligand outside the cell (such...
coat protein is a duplication consisting of two domains with a similar fold packed together like the nucleoplasmin subunits. Within a hexon trimer, the...
homotrimer is a protein which is composed of three identical units of polypeptide. Hemagglutinin (influenza) Spike protein (coronavirus) Proteintrimer Cha, S...
to give a trimer of hairpins. Examples of class II viral fusion proteins include the dengue virus E protein, and the west nile virus E protein. Class III:...
fusion. Class I fusion proteins resemble influenzavirus hemagglutinin in their structure. Post-fusion, the active site has a trimer of α-helical coiled-coils...
by a receptor, Gα is bound to GDP and to Gβγ to form the inactive G proteintrimer. When the receptor binds an activating ligand outside the cell (such...
formed from a trimer. Actin protein dimers and trimers are energetically unfavorable. Actin nucleators like the Arp2/3 complex of proteins from the formin...
be found a limited number of the envelope glycoprotein (Env) of HIV, a trimer formed by heterodimers of gp120 and gp41. Env is responsible for binding...
capsid protein. The virion is organized in T=3 icosahedral symmetry, which means there are 60 triangular subunits each made up of 3 viral capsid proteins. The...
the Greek prefix denoting that number, with the ending -mer: thus dimer, trimer, tetramer, pentamer, and hexamer refer to molecules with two, three, four...
Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers – specifically polypeptides – formed...
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random...
Legumin is a hexameric protein, and vicilin proteins are trimers. Pea protein is considered to be an almost complete protein, containing all the essential...
graphics that produced the ribbon image at top right (other examples: 1XK8 trimer and DNA polymerase). Since their inception, and continuing in the present...
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