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Tumor initiation information


Tumor initiation is defined as "a process in which normal cells are changed so that they are able to form tumors".[1] It is the first phase in tumor development.[2] Mutagens, substances that cause cancer can be tumor initiators.

  1. ^ "tumor initiation". National Cancer Institute. Retrieved 9 Nov 2012.
  2. ^ Compton C (2020). "Cancer initiation, promotion, and progression and the acquisition of key behavioral traits.". Cancer: The Enemy from Within. Cham: Springer. pp. 25–48. doi:10.1007/978-3-030-40651-6_2.

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Tumor initiation

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Tumor initiation is defined as "a process in which normal cells are changed so that they are able to form tumors". It is the first phase in tumor development...

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Neoplasm

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unknown primary origin. Neoplastic tumors are often heterogeneous and contain more than one type of cell, but their initiation and continued growth are usually...

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Transcription factor Jun

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of c-jun can largely suppress tumor formation. Also, c-jun is required for tumor cell survival between the initiation and progression stages. In contrast...

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Tumor progression

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nuclear polymorphism.[citation needed] Tumor initiation Tumor promotion Compton C (2020). "Cancer initiation, promotion, and progression and the acquisition...

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Tumor promotion

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VEGF, or Akt. Phorbol myristate acetate Tumor initiation Tumor progression Compton C (2020). "Cancer initiation, promotion, and progression and the acquisition...

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Tumor microenvironment

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from tumor cells. Stromal cells contribute to tumor initiation, progression and drug resistance, and the stroma is known to evolve as the tumor develops...

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Benign tumor

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A benign tumor is a mass of cells (tumor) that does not invade neighboring tissue or metastasize (spread throughout the body). Compared to malignant (cancerous)...

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Sanford Burnham Prebys Medical Discovery Institute

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Prebys: Insights into the complex system of networks and mechanisms that tumors use to survive and proliferate. Findings build dialogue with clinicians...

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Colorectal cancer

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changes in the local microenvironment on neoplastic evolution from tumor initiation to death. Epigenetic alterations are much more frequent in colon cancer...

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Methylsulfonylmethane

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STAT5b, IGF-1R and VEGF, confirming the ability of MSM to suppress tumor initiation, growth and metastasis in a dose dependent manner. The expression of...

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Oligodendroglioma

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study illustrated a 69% correlation between NJDS gene mutation and the tumor initiation.[citation needed] A single case report has linked oligodendroglioma...

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Initiation factor

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binding and scanning. In cancerous cells, initiation factors assist in cellular transformation and development of tumors. The survival and growth of cancer is...

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Carcinogenesis

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driver events per tumor, of which 0.6 are point mutations in oncogenes, 1.5 are amplifications of oncogenes, 1.2 are point mutations in tumor suppressors,...

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Mammary gland

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White, J. G.; Keely, P. J. (2008). "Collagen density promotes mammary tumor initiation and progression". BMC Medicine. 6: 11. doi:10.1186/1741-7015-6-11....

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Comparative oncology

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cancer, head and neck cancer, soft tissue sarcomas and bladder cancer. Tumor initiation and progression are influenced by age, nutrition, sex, reproduction...

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Tumor necrosis factor

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Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is a cytokine and member of the TNF superfamily...

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Lactate dehydrogenase

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the presence of encephalitis and poor prognosis. LDH is involved in tumor initiation and metabolism. Cancer cells rely on increased glycolysis resulting...

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Cancer

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invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal...

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Hedgehog signaling pathway

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survival, and the presence of cancer stem cells, which contribute to tumor initiation and progression. Vismodegib FDA approved (Jan 2012) for basal cell...

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Retinoblastoma protein

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"pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia". PLOS Biology. 2 (2): E22....

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Human herpesvirus 6

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Elena; Brown, Jay; et al. (2011). "The roles of viruses in brain tumor initiation and oncomodulation". Journal of Neuro-Oncology. 105 (3): 451–66. doi:10...

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Breast cancer stem cell

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a subset of tumor cells known as breast cancer stem cells (BCSCs). These cells possess the abilities of self-renewal and tumor initiation, allowing them...

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Gingerol

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skin cancer which targeted the activator proteins associated with tumor initiation. Gingerol compounds inhibited the transformation of normal cells into...

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Phyllodes tumor

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Phyllodes tumors (from Greek: phullon), are a rare type of biphasic fibroepithelial mass that form from the periductal stromal and epithelial cells of...

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