Surroundings of tumors including nearby cells and blood vessels
Component of the tumor microenvironment (TME). The tumor microenvironment is a complex system of various tumor cells, stromal cells, and immune cells.[1]
The tumor microenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells, fibroblasts and signaling molecules) and the extracellular matrix.[2][3][4][5] Mutual interaction between cancer cells and the different components of the tumor microenvironment support its growth and invasion in healthy tissues which correlates with tumor resistance to current treatments and poor prognosis. The tumor microenvironment is in constant change because of the tumor's ability to influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells.[2][6][7][8][9]
^Piñeiro Fernández J, Luddy KA, Harmon C, O'Farrelly C (2019). "Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function". International Journal of Molecular Sciences. 20 (17): 4131. doi:10.3390/ijms20174131. ISSN 1422-0067. PMC 6747260. PMID 31450598.
^Spill F, Reynolds DS, Kamm RD, Zaman MH (August 2016). "Impact of the physical microenvironment on tumor progression and metastasis". Current Opinion in Biotechnology. 40: 41–48. doi:10.1016/j.copbio.2016.02.007. PMC 4975620. PMID 26938687.
^Cite error: The named reference Weber was invoked but never defined (see the help page).
^Korneev KV, Atretkhany KN, Drutskaya MS, Grivennikov SI, Kuprash DV, Nedospasov SA (January 2017). "TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis". Cytokine. 89: 127–135. doi:10.1016/j.cyto.2016.01.021. PMID 26854213.
^Ghoshdastider U, Rohatgi N, Mojtabavi Naeini M, Baruah P, Revkov E, Guo YA, et al. (April 2021). "Pan-Cancer Analysis of Ligand-Receptor Cross-talk in the Tumor Microenvironment". Cancer Research. 81 (7): 1802–1812. doi:10.1158/0008-5472.CAN-20-2352. PMID 33547160. S2CID 232432582.
^Žavbi J, Breznik B (2021). "Modelling the microenvironment of the most aggressive brain tumours for preclinical studies". Advances in Cancer Biology - Metastasis. 3: 100017. doi:10.1016/j.adcanc.2021.100017. ISSN 2667-3940. S2CID 244452599.
^Xinyuan T, Lei Y, Jianping S, Rongwei Z, Ruiwen S, Ye Z, et al. (2023-10-01). "Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)". Oncology Reports. 50 (4): 1–15. doi:10.3892/or.2023.8618. ISSN 1021-335X. PMC 10485805. PMID 37615187.
and 24 Related for: Tumor microenvironment information
The tumormicroenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells...
essential to maintain self-tolerance. In a tumor, however, Tregs form an immunosuppressive microenvironment. Tumor cells produce special cytokines (such as...
site of many tumors. Studies in both humans and animal models have implicated that high numbers of Treg cells in the tumormicroenvironment is indicative...
tumor cells. See the Natural killer cell page for further information on NK cells in tumor surveillance. ILC1s influence the tumormicroenvironment by...
and their interactions all contribute to the changing tumormicroenvironment, which the tumor largely manipulates to be immunotolerant so as to avoid...
Mediated by Transmembrane Tumor Necrosis Factor-Alpha and TNF Receptor 2: Potential Roles in an Immunosuppressive TumorMicroenvironment". Frontiers in Immunology...
company. It develops oncology therapies designed to target the tumormicroenvironment. The company was founded in 1998 and went public in 2004. Halozyme...
cancer cells by influencing the tumormicroenvironment. Oncogenes build up an inflammatory pro-tumorigenic microenvironment. Hormones also play a role in...
mimicking the tumormicroenvironment. Alternatively, a single-cell suspension enables scientists to collect an unbiased sampling of the whole tumor, eliminating...
suppressed by the cancer cells. It asserts that the tumor would have been eliminated if the tumormicroenvironment had not been suppressive. Rather than employing...
downregulated. Tumor-associated macrophages (TAMs) have been shown to be abundantly present in the microenvironments of metastasizing tumors. Studies have...
Esparvarinha M, et al. (January 2021). "The role of hypoxia in the tumormicroenvironment and development of cancer stem cell: a novel approach to developing...
Controllability in Phenotypically Characterized Osteosarcoma: Role of TumorMicroenvironment". Frontiers in Immunology. 8: 918. doi:10.3389/fimmu.2017.00918...
Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the TumorMicroenvironment". Frontiers in Immunology...
2015). "The Multifaceted Roles Neutrophils Play in the TumorMicroenvironment". Cancer Microenvironment. 8 (3): 125–58. doi:10.1007/s12307-014-0147-5. PMC 4714999...
hyaluronic acid). This creates a tumormicroenvironment that is short of blood vessels (hypovascular) and so of oxygen (tumor hypoxia). It is thought that...
fewer side effects. Metronomic therapy is shown to affect both tumormicroenvironment and tumor cells to achieve its therapeutic effects. Metronomic therapy...
contribute to the acquisition of hallmark traits by creating the “tumormicroenvironment.” Recognition of the widespread applicability of these concepts...
A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics from a primary tumor and is carried around the body in the blood...
cancer development for example through production of IL-17 in the tumormicroenvironment, which promotes angiogenesis and cell growth or because their ability...
encephalopathy Trimethylolethane, a triol, an organic compound Tumormicroenvironment Tickle Me Elmo This disambiguation page lists articles associated...
Ontong P, Itano N (May 2016). "Hyaluronan: A modulator of the tumormicroenvironment". Cancer Letters. 375 (1): 20–30. doi:10.1016/j.canlet.2016.02.031...
tumour cells help to foster an immunosuppressive tumour microenvironment. During the escape phase, tumor cell variants selected in the equilibrium phase have...
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