Not to be confused with Tryptan (the trade name of amino acid tryptophan) or the hydrocarbon triptane or Oxitriptan.
Triptans
Drug class
Chemical structure of sumatriptan, the prototypical triptan
Class identifiers
Use
Migraine, cluster headache
ATC code
N02CC
Biological target
5-HT1B receptor, 5-HT1D receptor
Legal status
In Wikidata
Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches. This drug class was first commercially introduced in the 1990s. While effective at treating individual headaches, they do not provide preventive treatment and are not considered a cure. They are not effective for the treatment of tension–type headache,[1] except in persons who also experience migraines.[2] Triptans do not relieve other kinds of pain.
The drugs of this class act as agonists for serotonin 5-HT1B and 5-HT1D receptors at blood vessels and nerve endings in the brain. The first clinically available triptan was sumatriptan, which has been marketed since 1991. Triptans have largely replaced ergotamines, an older class of medications used to relieve migraine and cluster headaches.[3]
^Mutschler, Ernst; Gerd Geisslinger; Heyo K. Kroemer; Sabine Menzel; Peter Ruth (2013). Arzneimittelwirkungen (in German) (10 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 233–4. ISBN 978-3-8047-2898-1.
^Green, Mark W. (2015). "Overview of Migraine: Recognition, Diagnosis, and Pathophysiology". In Diamond, Seymour; Cady, Roger K.; Diamond, Merle L.; Green, Mark W.; Martin, Vincent T. (eds.). Headache and Migraine Biology and Management. Academic Press. p. 44. ISBN 978-0-12-800901-7. Archived from the original on 2018-05-06 – via GoogleBooks.
Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches. This drug class was first...
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was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method. This reaction can be catalyzed...
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occur at the same time every day. Cluster headaches can be treated with triptans and prevented with prednisone, ergotamine or lithium. trigeminal neuralgia...
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contribute to their beneficial effects on negative symptoms in schizophrenia. Triptans such as sumatriptan, rizatriptan, and naratriptan are 5-HT1B receptor agonists...
dextromethorphan, buspirone, L-tryptophan, 5-hydroxytryptophan, St. John's wort, triptans, MDMA, metoclopramide, or cocaine. It occurs in about 15% of SSRI overdoses...
triggers. Treatments for acute attacks include oxygen or a fast-acting triptan. Measures recommended to decrease the frequency of attacks include steroid...
Analgesic Benzodiazepine Cardiac glycoside Fibrate Steroid Thiazide diuretic Triptan β-lactam antibiotic This type of categorisation is from a pharmacological...
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for nausea, and the avoidance of triggers. Specific medications such as triptans, ergotamines, or CGRP inhibitors may be used in those experiencing headaches...
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