Trimetaphan camsilate information

Trimetaphan camsilate
Clinical data
Trade names	Arfonad
Routes of; administration	Oral, IM, IV
ATC code	C02BA01 (WHO) ;
Pharmacokinetic data
Excretion	Renal, mostly unchanged
Identifiers
	IUPAC name 3,5-dibenzyl-4-oxo-8λ4-thia-3,5-diazatricyclo[6.3.0.02,6]undecan-8-ylium (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate;
CAS Number	68-91-7 ;
PubChem CID	23576;
DrugBank	DB01116 ;
UNII	8W556014K9;
KEGG	D00612;
ChEMBL	ChEMBL1245 ;
CompTox Dashboard (EPA)	DTXSID3023710 ;
ECHA InfoCard	100.000.633
Chemical and physical data
Formula	C22H25N2OS (free base)
Molar mass	365.52 g·mol−1
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Trimetaphan camsilate (INN) or trimethaphan camsylate (USAN), trade name Arfonad, is a sympatholytic drug used in rare circumstances to lower blood pressure.

Trimetaphan is a ganglionic blocker: it counteracts cholinergic transmission at a specific type of nicotinic acetylcholine receptors in the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic receptor, is short-acting, and is given intravenously.

It was discovered by Leo Sternbach.^[1]

^ Bause GS (1 August 2017). "From Coenzyme R to "Arfonad" and from Vitamin H to Hypotension". Anesthesiology. 127 (2): 381–381. doi:10.1097/ALN.0000000000001771. ISSN 0003-3022.

[1] Bause GS (1 August 2017). "From Coenzyme R to "Arfonad" and from Vitamin H to Hypotension". Anesthesiology. 127 (2): 381–381. doi:10.1097/ALN.0000000000001771. ISSN 0003-3022.

Trimetaphan camsilate information

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Trimetaphan camsilate

Camphorsulfonic acid

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Phosphatidylcholine

Pancuronium bromide

Nicotinic acetylcholine receptor

Cotinine

Pyrantel

Parasympathomimetic drug

Rocuronium bromide

Suxamethonium chloride

Varenicline

Curare

Lecithin

Datura

Tobacco

Brugmansia

Ganglionic blocker

Acetylcarnitine

Thiocolchicoside

Citicoline

Pantothenic acid

Pentobarbital

Vecuronium bromide

Anticholinergic

Dimenhydrinate

Olopatadine

Clinical data


Trade names	Arfonad
Routes of administration	Oral, IM, IV
ATC code	C02BA01 (WHO)
Pharmacokinetic data
Excretion	Renal, mostly unchanged
Identifiers
IUPAC name 3,5-dibenzyl-4-oxo-8λ⁴-thia-3,5-diazatricyclo[6.3.0.0^2,6]undecan-8-ylium (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate
CAS Number	68-91-7^Y
PubChem CID	23576
DrugBank	DB01116^N
UNII	8W556014K9
KEGG	D00612
ChEMBL	ChEMBL1245^N
CompTox Dashboard (EPA)	DTXSID3023710
ECHA InfoCard	100.000.633
Chemical and physical data
Formula	C₂₂H₂₅N₂OS (free base)
Molar mass	365.52 g·mol⁻¹
^NY (what is this?) (verify)