Trestolone, also known as 7α-methyl-19-nortestosterone (MENT), is an experimental androgen/anabolic steroid (AAS) and progestogen medication which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low testosterone levels in men but has never been marketed for medical use.[1][2][3][4][5] It is given as an implant that is placed into fat.[3] As trestolone acetate, an androgen ester and prodrug of trestolone, the medication can also be given by injection into muscle.[1][5]
Side effects of trestolone use in men include low estrogen levels and associated symptoms such as reduced sexual function and decreased bone mineral density among others.[5][3][6] Trestolone is an AAS, and hence is an agonist of the androgen receptor, the biological target of androgens like testosterone.[3][7] It is also a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.[3][7] Due to its androgenic and progestogenic activity, trestolone has antigonadotropic effects.[3][7] These effects result in reversible suppression of sperm production and are responsible for the contraceptive effects of trestolone in men.[3]
Trestolone was first described in 1963.[8] Subsequently, it was not studied again until 1990.[9] Development of trestolone for potential clinical use started by 1993 and continued thereafter.[4][10] No additional development appears to have been conducted since 2013.[3] The medication was developed by the Population Council, a non-profit, non-governmental organization dedicated to reproductive health.[3][11]
^ abJ. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 888–. ISBN 978-1-4757-2085-3.
^ abcdefghiNieschlag E, Kumar N, Sitruk-Ware R (2013). "7α-methyl-19-nortestosterone (MENTR): the population council's contribution to research on male contraception and treatment of hypogonadism". Contraception. 87 (3): 288–95. doi:10.1016/j.contraception.2012.08.036. PMID 23063338.
^ abCite error: The named reference pmid8489761 was invoked but never defined (see the help page).
^ abcCorona G, Rastrelli G, Vignozzi L, Maggi M (2012). "Emerging medication for the treatment of male hypogonadism". Expert Opin Emerg Drugs. 17 (2): 239–59. doi:10.1517/14728214.2012.683411. PMID 22612692. S2CID 22068249.
^Cite error: The named reference pmid12788888 was invoked but never defined (see the help page).
^ abcCite error: The named reference pmid22065861 was invoked but never defined (see the help page).
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^MENT – project information from the Population Council
Trestolone, also known as 7α-methyl-19-nortestosterone (MENT), is an experimental androgen/anabolic steroid (AAS) and progestogen medication which has...
Trestolone enanthate, also known as 7α-methyl-19-nortestosterone 17β-enanthate (MENT enanthate), is an androgen and anabolic steroid (AAS) and progestogen...
Trestolone acetate (USANTooltip United States Adopted Name; developmental code names CDB-903, NSC-69948, U-15614; also known as 7α-methyl-19-nortestosterone...
specific protein, a member of the serpin family of protease inhibitors Trestolone (7α-methyl-19-nortestosterone) a synthetic androgen developed for male...
5α-reductase. In addition, some 19-nortestosterone derivatives, including trestolone (7α-methyl-19-nortestosterone (MENT)), 11β-methyl-19-nortestosterone (11β-MNT)...
Dimethandrolone undecanoate Mesterolone cypionate Nisterime acetate Trestolone acetate Trestolone enantate Although not esters, the following ethers of synthetic...
17β-methoxycyclopentyl ether Prasterone enanthate Testosterone enanthate Trestolone enanthate This set index page lists chemical structure articles associated...
testosterone. In addition, 7α-alkyl substitution of testosterone (for example trestolone) has also been reported to increase its anabolic effects. However, efforts...
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