CKLF like MARVEL transmembrane domain-containing 6 (i.e. CMTM6), previously termed chemokine-like factor superfamily 6 (i.e. CKLFSF6), is a transmembrane protein encoded in humans by the CMTM6 gene (also termed the CKLFSF6, PRO2219, ayoube, or gourari gene). This gene is located in band 22.3 on the short (or "p") arm of chromosome 3.[5] CMTM6 protein belongs to the CKLF-like MARVEL transmembrane domain-containing family of proteins.[6] This family consist of 9 member proteins: CKLF and CMTM1 through CMTM8.[7][8] The CMTM family proteins are involved in autoimmune diseases, cardiovascular diseases, the male reproductive system, haematopoiesis, and cancer development.[8] CMTM6 protein regulates immune responses to normal and abnormal (particularly cancerous) cells.[9][10]
^ abcGRCh38: Ensembl release 89: ENSG00000091317 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032434 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (June 2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.
^Lu J, Wu QQ, Zhou YB, Zhang KH, Pang BX, Li L, Sun N, Wang HS, Zhang S, Li WJ, Zheng W, Liu W (2016). "Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain-Containing Member Family (Review)". Asian Pacific Journal of Cancer Prevention. 17 (6): 2741–4. PMID 27356683.
^ abWu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.
expressed PD-L1 also expressed CMTM6 protein (i.e. CKLFlikeMARVELtransmembranedomaincontaining6 protein). Strong PD‑L1 expression proved to be a poor...
CKLF-likeMARVELtransmembranedomain-containing protein 3 (i.e. CMTM3), also termed chemokine-like factor superfamily 3 (i.e. CKLFSF3), is a member of...
CKLF-likeMARVELtransmembranedomain-containing protein 2 (i.e. CMTM2), previously termed chemokine-like factor superfamily 2 ( i.e. CKLFSF2), is a member...