Escherichia coli rhomboid protease GlpG in complex with a beta-lactam inhibitor (yellow) bound to the catalytic serine residue. From PDB: 3ZMH.[1]
Identifiers
Symbol
Rhomboid
Pfam
PF01694
Pfam clan
CL0207
InterPro
IPR002610
MEROPS
S54
SCOP2
144092 / SCOPe / SUPFAM
OPM superfamily
165
OPM protein
2ic8
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The rhomboid proteases are a family of enzymes that exist in almost all species. They are proteases: they cut the polypeptide chain of other proteins. This proteolytic cleavage is irreversible in cells, and an important type of cellular regulation. Although proteases are one of the earliest and best studied class of enzyme, rhomboids belong to a much more recently discovered type: the intramembrane proteases. What is unique about intramembrane proteases is that their active sites are buried in the lipid bilayer of cell membranes, and they cleave other transmembrane proteins within their transmembrane domains.[2] About 30% of all proteins have transmembrane domains, and their regulated processing often has major biological consequences. Accordingly, rhomboids regulate many important cellular processes, and may be involved in a wide range of human diseases.
^Vinothkumar KR, Pierrat OA, Large JM, Freeman M (June 2013). "Structure of rhomboid protease in complex with β-lactam inhibitors defines the S2' cavity". Structure. 21 (6): 1051–8. doi:10.1016/j.str.2013.03.013. PMC 3690538. PMID 23665170.
^Brown MS, Ye J, Rawson RB, Goldstein JL (February 2000). "Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans". Cell. 100 (4): 391–8. doi:10.1016/S0092-8674(00)80675-3. PMID 10693756. S2CID 12194770.
The rhomboidproteases are a family of enzymes that exist in almost all species. They are proteases: they cut the polypeptide chain of other proteins...
Presenilins-associated rhomboid-like protein, mitochondrial (PSARL), also known as PINK1/PGAM5-associated rhomboid-like protease (PARL), is an inner mitochondrial...
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's)...
helix. Some others are multi-span transmembrane proteins, for example rhomboidprotease. The word hydrolase (/ˈhaɪdroʊleɪs, -leɪz/) suffixes the combining...
Thammahong A, Beattie SR, Bultman KM, Cramer RA (2016). "RbdB, a RhomboidProtease Critical for SREBP Activation and Virulence in Aspergillus fumigatus"...
proteins from the outer bacterial membrane Methane monooxygenase Rhomboidprotease Disulfide bond formation protein (DsbA-DsbB complex) T cell receptor...
Castro, Rosana; Cuoto, Alicia; Gimenez, Maria (April 18, 2014). "A RhomboidProtease Gene Deletion Affects a Novel Oligosaccharide N-Linked to the S-layer...
membrane-associated proteases, but apparently also to the smaller set of intramembrane cleaving proteases, along with the rhomboidprotease RhoII, and in contrast...
generate structure-function relationships of these rhomboidproteases. She uncovered the rhomboidprotease of Haemophilus influenzae. During the COVID-19...
theoretical pI of 7.53. Skd3 is further processed by the mitochondrial rhomboidprotease PARL at amino acid 127. Skd3 has a specific C-terminal D2 domain and...
Drosophila is a useful in vivo tool to analyze Alzheimer's disease. Rhomboidproteases were first detected in Drosophila but then found to be highly conserved...
of the histidine. Similarly, RHBDF1 is a homolog of the S54 family rhomboidproteases with an alanine in the place of the nucleophilic serine. In some cases...
that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases. The RHBDF2 gene is located on the long arm of chromosome...
Anthony D.; Benning, Christoph (September 2019). "A predicted plastid rhomboidprotease affects phosphatidic acid metabolism in Arabidopsis thaliana". The...
that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases. GRCh38: Ensembl release 89: ENSG00000007384 – Ensembl...
zygotic genes decapentaplegic (dpp), zerknüllt, tolloid, twist, snail, and rhomboid due to the expression of dorsal in the nucleus. High levels of dorsal are...
lead to the expression of rhomboid which identifies future neuroectoderm. More dorsally, active Dpp signaling represses rhomboid thus confining it to the...
products are removed. Fluoride may also indirectly alter the action of protease via a decrease in the availability of free calcium ions in the mineralization...
Common causes of drug-related cheilitis include Etretinate, Indinavir, Protease inhibitors, Vitamin A and Isotretinoin (a retinoid drug). Uncommon causes...
The flb gene also has interactions with the proteins Rhomboid and Star. Rhomboid is a protease that cleaves ligands such as Spitz so that they can come...
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