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Transcription translation feedback loop information


Transcription-translation feedback loop (TTFL) is a cellular model for explaining circadian rhythms in behavior and physiology. Widely conserved across species, the TTFL is auto-regulatory, in which transcription of clock genes is regulated by their own protein products.

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Transcription translation feedback loop

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Transcription-translation feedback loop (TTFL) is a cellular model for explaining circadian rhythms in behavior and physiology. Widely conserved across...

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Feedback

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Feedback occurs when outputs of a system are routed back as inputs as part of a chain of cause-and-effect that forms a circuit or loop. The system can...

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Oscillating gene

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behind an oscillating gene is best described as a transcription/translation feedback loop. This loop contains both positive regulators, which increase...

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AVP gene

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responses to stress. Expression of AVP is regulated by the transcription translation feedback loop (TTFL), which is an important part of the circadian system...

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KaiB

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Synechococcus circadian clock. Initially, it was thought that a transcription-translation feedback loop was necessary in creating circadian rhythms so it was believed...

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Circadian clock

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timing in the absence of transcription, i.e. there was no requirement for a transcription-translation autoregulatory feedback loop for rhythms. Moreover...

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Circadian rhythm

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through a transcription-translation feedback loop. The core clock mechanism consists of two interdependent feedback loops, namely the PER/TIM loop and the...

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KaiC

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cyanobacteria slave circadian clock is also based on a transcription translation feedback loop (TTFL). KaiC protein has both auto-kinase and auto-phosphatase...

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Vasopressin

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transcription-translation feedback loop (TTFL), Per2 protein accumulates and is phosphorylated by CK1E. Per2 subsequently inhibits the transcription factors...

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Suprachiasmatic nucleus

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driven by a transcription-translation negative feedback loop (TTFL) composed of interacting positive and negative transcriptional feedback loops. Within the...

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Michael Rosbash

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the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered...

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Transcription factor

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implication of this is that transcription factors can regulate themselves. For example, in a negative feedback loop, the transcription factor acts as its own...

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KaiA

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(PTO) that facilitates the oscillation of the larger transcription translation negative feedback loop (TTFL). The TTFL drives gene expression and replenishes...

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Biological tests of necessity and sufficiency

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circadian post-translation oscillator that regulates the clock in S. elongatus, in tandem with transcription-translation feedback loop (TTFL) model as...

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Regulation of gene expression

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coupled with a positive feedback loop creating an oscillator by taking advantage in the time delay of transcription and translation, given that the mRNA...

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Gene regulatory network

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genes are turned on and making proteins. Sometimes a 'self-sustaining feedback loop' ensures that a cell maintains its identity and passes it on. Less understood...

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Familial sleep traits

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stimuli (usually a light-dark cycle) and is regulated by a transcription-translation feedback loop (TTFL). In humans, there are multiple genes involved in...

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Bunker experiment

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based on molecular oscillations, using transcription-translation feedback loops and metabolic feedback loops. External cues, notably light, interact...

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CREB

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clock to light/dark cycles inhibits its own transcription via a transcription-translation feedback loop which can advance or delay the circadian clock...

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Monarch butterfly migration

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Drosophila and mammals, the monarch circadian clock uses a transcription translation feedback loop (TTFL) to drive rhythms in the mRNA and protein levels...

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Trp operon

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begin translating the mRNA while RNA polymerase is still transcribing the DNA sequence. This allows the process of translation to affect transcription of...

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Bacterial circadian rhythm

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first, the cyanobacterial clockwork appeared to be a transcription and translation feedback loop in which clock proteins autoregulate the activity of...

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