kaiA is a gene in the "kaiABC" gene cluster that plays a crucial role in the regulation of bacterial circadian rhythms, such as in the cyanobacterium Synechococcus elongatus.[1] For these bacteria, regulation of kaiA expression is critical for circadian rhythm, which determines the twenty-four-hour biological rhythm. In addition, KaiA functions with a negative feedback loop in relation with kaiB and KaiC. The kaiA gene makes KaiA protein that enhances phosphorylation of KaiC while KaiB inhibits activity of KaiA.[2]
^Markson JS, O'Shea EK (December 2009). "The molecular clockwork of a protein-based circadian oscillator". FEBS Letters. 583 (24): 3938–3947. doi:10.1016/j.febslet.2009.11.021. PMC 2810098. PMID 19913541.
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