Topical tac is a topical anesthetic solution[1] introduced by Pryor et al. in 1980. It is a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride (hence the "TAC" nomenclature). It has been used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly. Use in the pediatric patient cohort has been documented, including when children have been injured in the eye, ear, or other sensitive locations.[2][3][4]
Due to drug diversion concerns surrounding the use of cocaine in medicine, along with concern regarding toxicity and expense, the cocaine was replaced with lidocaine and a new anesthetic was created - lidocaine, epinephrine, and tetracaine (LET).[5]
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^Tipton, G. A.; DeWitt, G. W.; Eisenstein, S. J. (1 November 1989). "Topical TAC (tetracaine, adrenaline, cocaine) solution for local anesthesia in children: prescribing inconsistency and acute toxicity". Southern Medical Journal. 82 (11): 1344–1346. doi:10.1097/00007611-198911000-00004. PMID 2814620.
^Appleton's Nursing Manual - "Cocaine"
^Anderson, A. B.; Colecchi, C.; Baronoski, R.; DeWitt, T. G. (May 1990). "Local anesthesia in pediatric patients: topical TAC versus lidocaine". Annals of Emergency Medicine. 19 (5): 519–522. doi:10.1016/s0196-0644(05)82182-1. ISSN 0196-0644. PMID 2184706. S2CID 72722229.
^Königs, Ingo; Wenskus, Julia; Boettcher, Johannes; Reinshagen, Konrad; Boettcher, Michael (December 2020). "Lidocaine-Epinephrine-Tetracaine Gel Is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study". European Journal of Pediatric Surgery. 30 (6): 512–516. doi:10.1055/s-0039-3400283. ISSN 1439-359X. PMID 31739347. S2CID 208170240.
^Achar, Suraj; Kundu, Suriti (2002-07-01). "Principles of Office Anesthesia Part II: Topical Anesthesia". American Family Physician. 66 (1): 99–102. ISSN 0002-838X. PMID 12126037.
Topicaltac is a topical anesthetic solution introduced by Pryor et al. in 1980. It is a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10%...
tacrolimus (TAC) (SRL: r2 = 0.83; TAC: r2 = 0.82), so only one level need be taken to know its pharmacokinetic (PK) profile. PK profiles of SRL and of TAC are...
find an improvement in first-attempt cannulations. Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine...
epinephrine One combination product of this type is used topically for surface anaesthesia, TAC (5–12% tetracaine,1/2000 (0.05%, 500 ppm, 1⁄2 per mille)...
focus and topicalization is heavily used. A sentence constituent may be topicalized by placing it at the beginning of the sentence. Topicalization of the...
shows such as Choose Up Sides, Dough Re Mi, and the daytime version of Tic Tac Dough. On radio, Rayburn became one of the many hosts of the NBC program...
producers Dan Enright and Albert Freedman, originally, to appear on Tic-Tac-Dough, another game they produced. Van Doren eventually revealed—five decades...
bookmaker himself, at which he admitted to having failed. He then became a tic-tac man. He began his career in journalism at The Sporting Life, where he twice...
not treat distributed metastases or micrometastases.[citation needed] Topical chemotherapies, such as 5-fluorouracil, are used to treat some cases of...
and chess. Games of strategy include checkers, chess, Go, arimaa, and tic-tac-toe, and often require special equipment to play them. Games of chance include...
Center. Retrieved May 11, 2016. "Domestic and Antarctic Names - State and Topical Gazetteer Download Files: National Federal Codes" (CSV). United States...
Yavaş, Ö. (2012). "The status and road map of Turkish Accelerator Center (TAC)". Journal of Physics: Conference Series. 347 (1): 012008. Bibcode:2012JPhCS...
August 2009). "Animator David Silverman and Producer Josh Selig to Headline TAC". Animation World Network. "Legacy Content - Tarzan: The Musical". Laughing...
front of players. Panel shows can have any number of themes. Many are topical and satirical, such as Wait Wait... Don't Tell Me!, Have I Got News for...
simultaneous move game. Examples of perfect-information games include tic-tac-toe, checkers, chess, and Go. Many card games are games of imperfect information...
Pike Place Market, the Sorrento Hotel, Alki Beach, the Fremont Bridge, SeaTac Airport, the Dahlia Lounge, and several 1st Avenue shops. The filmmakers...
five-day-a-week entries like Jack Barry's The Joker's Wild (1977) and Tic-Tac-Dough (1978), the move of Match Game's daily run from CBS to syndication...
Romanian radio station Kiss FM (Romania). His style of humour is based on topical events, dark humour and the use of edgy one-liners. Sergiu started doing...
Two companies that led the PC market for a time were Globalink and MicroTac, following which a merger of the two companies (in December 1994) was found...
the Caesars". Eigler notes that Tertullian's passage is an "Anspielung auf Tac. ann 15, 44; Suet. Nero 16, 2"; see Ulrich Eigler, Lectiones vetustatis,...
of Military History. Willbanks, James H. (2017-11-16). Vietnam War: A Topical Exploration and Primary Source Collection [2 volumes]. ABC-CLIO. pp. 200–201...
this solution is being developed into a possible HIV entry-inhibiting topical microbicide. CCL5 has been shown to interact with CCR3, CCR5 and CCR1....
art once it is dispatched. Mail artists regularly call for thematic or topical mail art for use in (often unjuried) exhibition. Mail artists appreciate...
antibodies has been shown to relieve inflammatory arthritis and osteoarthritis. Topical steroids have been found to be an effective tool in normalizing levels...
Global Information