Organification is a biochemical process that takes place in thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO).[1]
Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".[2]
Thionamides can block organification.[3]
^Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p1181.
^Endocrine Physiology, Patricia E. Molina, third edition, p81.
^Aronson, J. K., ed. (2016-01-01), "Thionamides", Meyler's Side Effects of Drugs (Sixteenth Edition), Oxford: Elsevier, pp. 874–889, doi:10.1016/b978-0-444-53717-1.01537-7, ISBN 978-0-444-53716-4, retrieved 2021-02-18
Organification is a biochemical process that takes place in thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid...
peroxidase oxidizes iodide to atomic iodine (I) or iodinium (I+). The "organification of iodine," the incorporation of iodine into thyroglobulin for the production...
iodide/chloride transporter. In the thyroid, this leads to reduced organification of iodine (i.e. its incorporation into thyroid hormone). People with...
treat patients with hyperthyroidism due to its ability to inhibit the organification process in thyroid hormone synthesis, the so-called Wolff–Chaikoff effect...
thyroid iodide transport and, at high doses, competes with iodide in the organification process within thyroid tissue. Goitres may develop when there is a dietary...
carbon 5 of tyrosine residues of thyroglobulin in a process called organification of iodine. The iodination of specific tyrosines yields monoiodotyrosine...
disorder characterized by sensorineural hearing loss, goiter and a partial organification problem detectable by a positive perchlorate test. Pendrin is responsible...
imaging of the thyroid, although it specifically measures uptake and not organification. It has also been used historically to evaluate for testicular torsion...
have been reported in specific pedigrees or colonies including iodine organification and thyroid peroxidase deficiency. Prognosis is guarded and the issues...
124I uptake by the thyroid is impaired. Kcne2 deletion does not impair organification of iodide once it has been taken up by NIS. Pups raised by Kcne2-/-...
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