The thyroid hormone receptor (TR)[1] is a type of nuclear receptor that is activated by binding thyroid hormone.[2] TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.[3]
^Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B (January 1984). "Chromosomal localisation of the human homologues to the oncogenes erbA and B". The EMBO Journal. 3 (1): 159–63. doi:10.1002/j.1460-2075.1984.tb01777.x. PMC 557313. PMID 6323162.
^Flamant F, Baxter JD, Forrest D, Refetoff S, Samuels H, Scanlan TS, et al. (December 2006). "International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors". Pharmacological Reviews. 58 (4): 705–11. doi:10.1124/pr.58.4.3. PMID 17132849. S2CID 20478309.
^Kublaoui B, Levine M (2014). Pediatric Endocrinology (Fourth ed.). Philadelphia, PA: Saunders. pp. 34–89. ISBN 978-1-4557-4858-7.
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