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IUPAC definition
Property of a material (or substance) that induces and/or promotes the formation of a thrombus.[1]
Thrombogenicity refers to the tendency of a material in contact with the blood to produce a thrombus, or clot. It not only refers to fixed thrombi but also to emboli, thrombi which have become detached and travel through the bloodstream. Thrombogenicity can also encompass events such as the activation of immune pathways and the complement system. All materials are considered to be thrombogenic[citation needed] with the exception of the normal state of endothelial cells which line blood vessels.[2] Certain medical implants appear non-thrombogenic due to high flow rates of blood past the implant, but in reality all are thrombogenic to a degree. Various surface treatments are available to minimize these thrombogenic effects.
A thrombogenic implant will eventually be covered by a fibrous capsule, the thickness of this capsule can be considered one measure of thrombogenicity, and if extreme can lead to the failure of the implant.
^Vert, Michel; Doi, Yoshiharu; Hellwich, Karl-Heinz; Hess, Michael; Hodge, Philip; Kubisa, Przemyslaw; Rinaudo, Marguerite; Schué, François (2012). "Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)" (PDF). Pure and Applied Chemistry. 84 (2): 377–410. doi:10.1351/PAC-REC-10-12-04. S2CID 98107080.
substance) that induces and/or promotes the formation of a thrombus. Thrombogenicity refers to the tendency of a material in contact with the blood to produce...
sufficient blood flow for the metabolic needs of the downstream tissue. Thrombogenicity (the tendency to clot) National Blood Clot Alliance Hemorrhoid Pretorius...
pickling to break down bulk material near the surface.[citation needed] Thrombogenicity, a material’s tendency to induce clot formation, is an important factor...
triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity, among others, that play a role in cardiovascular disease. Different...
12-hydroxyeicosatetraenoic acid in the subendothelial matrix and reduced thrombogenicity of the subendothelial matrix. Pretreatment it reduced reperfusion injury...
usually weak and prone to rupture. Ruptures of the fibrous cap expose thrombogenic material, such as collagen, to the circulation and eventually induce...
triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity, among others, that play a role in CVD, although it seems, in the absence...
biocompatibility, chemical inertness, lubricity, sterility, asepsis, thrombogenicity, susceptibility to corrosion, degradation, and hydrophilicity. Teflon...
[citation needed] An ideal tissue engineered heart valve would be non‐thrombogenic, biocompatible, durable, resistant to calcification, grow with the surrounding...
macrophages or by intravascular shear force from blood flow, subendothelial thrombogenic material (extracellular matrix) is exposed to circulating platelets and...
therapy is somewhat controversial due to the known carcinogenic and thrombogenic properties of estrogen; however, many physicians and patients feel the...
appear to attach to the blood vessel wall endothelium, normally a non-thrombogenic surface, with fibrin. Platelets in venous thrombi attach to downstream...
anticoagulant therapy 4 with Major surgery with prolonged immobilization 4 Known thrombogenic mutations 4 Current and history of ischemic heart diseaase 4 Stroke (history...
thrombotic agents that promote blood clots, such as surgicel and gelfoam. The thrombogenic foams and gels do not require removal and dissolve after a few days....
β-antithrombin is more important than α-antithrombin in controlling thrombogenic events resulting from tissue injury. Indeed, thrombin inhibition after...
(August 1998). "Antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms". The American Journal of the Medical Sciences. 316 (2): 142–151...
PMID 17137719. S2CID 17111045. Horstkotte D, Bergemann R (March 2001). "Thrombogenicity of the St. Jude medical prosthesis with and without silzone-coated...
increased risk of thrombosis such as postpartum, history of thrombosis, thrombogenic mutations, systemic lupus erythematosus, diabetes, and hypertension....
component of the outer surface of the erythrocyte bilayer was non-thrombogenicity. Until 2002, over 120,000 phosphorylcholine-coated stents have been...
arachidonic acid is then metabolized to form several inflammatory and thrombogenic molecules. Excess levels of sPLA2 is thought to contribute to several...
Wolner E, Weigel G, Simon P. Decellularization does not eliminate thrombogenicity and inflammatory stimulation in tissue-engineered porcine heart valves...
affiliated (as spin-offs) with the university and its research. IMEC, Thrombogenics - now Oxurion and Materialise NV are some of the most important. The...
microvesicles isolated from cardiac surgery patients were found to be thrombogenic in both in vitro assays and in rats. Microvesicles isolated from healthy...
coronary artery disease (current or history) Valvular heart disease with thrombogenic complications Severe hypertension Diabetes with vascular involvement...
particular advantage in the current form but may be used to study low flow thrombogenic states like spontaneous echo contrasts.The study of tissue Doppler has...
patients have been implanted to date with stents containing this non-thrombogenic coating. Zotarolimus is an analog made by substituting a tetrazole ring...
antibody-mediated disruption of the annexin-V antithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome". J. Autoimmun. 15 (2): 107–11...
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