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A ternary complex is a protein complex containing three different molecules that are bound together. In structural biology, ternary complex can also be used to describe a crystal containing a protein with two small molecules bound, such as a cofactor and a substrate; or a complex formed between two proteins and a single substrate.[1] In Immunology, ternary complex can refer to the MHC–peptide–T-cell-receptor complex formed when T cells recognize epitopes of an antigen.
Another important example is the ternary complex formed during eukaryotic translation, in which ternary complex composed of eIF2 + GTP + Met-tRNAiMet is formed.[2]
A ternary complex can be a complex formed between two substrate molecules and an enzyme. This is seen in multi-substrate enzyme-catalyzed reactions where two substrates and two products can be formed. The ternary complex is an intermediate species in this type of enzyme-catalyzed reaction. An example for a ternary complex is seen in the random-order mechanism or the compulsory-order mechanism of enzyme catalysis for multiple substrates.[3]
The term ternary complex can also refer to a polymer formed by electrostatic interactions.[4]
^Clar, Steven G.; Tamanoi, Fuyuhiko (2006). Protein methyltransferass. Academic Press. pp. 162–172. ISBN 978-0-12-122725-8.
^Robert, Francis; Kapp, Lee D.; Khan, Shakila N.; Acker, Michael G.; Kolitz, Sarah; Kazemi, Shirin; Kaufman, Randal J.; Merrick, William C.; Koromilas, Antonis E.; Lorsch, Jon R.; Pelletier, Jerry (November 2006). Schmid, Sandra (ed.). "Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNA i Met Ternary Complex Availability". Molecular Biology of the Cell. 17 (11): 4632–4644. doi:10.1091/mbc.e06-06-0478. ISSN 1059-1524. PMC 1635388. PMID 16928960.
^Hindson, V. John; Shaw, William V. (2003-03-01). "Random-Order Ternary Complex Reaction Mechanism of Serine Acetyltransferase from Escherichia coli". Biochemistry. 42 (10): 3113–3119. doi:10.1021/bi0267893. ISSN 0006-2960. PMID 12627979.
^Cabuil, Valérie; Levitz, Pierre; Treiner, Clande (2004). Trends in colloid and interface science XVII. Springer. p. 45. ISBN 978-3-540-20073-4.
A ternarycomplex is a protein complex containing three different molecules that are bound together. In structural biology, ternarycomplex can also be...
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mechanism: ternarycomplex and ping–pong. In these enzymes, both substrates bind to the enzyme at the same time to produce an EAB ternarycomplex. The order...
agonists), describing them as two independent events. The original Ternarycomplex model was used to describe ligand, receptor, and G-protein interactions...
A ternary /ˈtɜːrnəri/ numeral system (also called base 3 or trinary) has three as its base. Analogous to a bit, a ternary digit is a trit (trinary digit)...
eIF1A, eIF3, and the eIF2-Met-tRNAiMet-GTP ternarycomplex (eIF2-TC). The 43S is an important intermediate complex during cap-dependent translation initiation...
degrees of complexity than ternary phases. With four elements, quaternary phases are more complex. The number of isomers of a ternary compound provide a distinction...
stream of the patient in the form of binary complex with TnC or ternarycomplex with cTnT and TnC. cTnI-TnC complex formation plays an important positive role...
proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (EC 3.4.21.5, fibrinogenase, thrombase...
GTP. eIF2 is an essential factor for protein synthesis that forms a ternarycomplex (TC) with GTP and the initiator Met-tRNAiMet. After its formation,...
most such pieces were in proper compound ternary form). In a complexternary form each section is itself in ternary form in the scheme of [(A–B–A)(C–D–C)(A–B–A)]...
strong electrostatic interaction with thrombin. The formation of a ternarycomplex between AT, thrombin, and heparin results in the inactivation of thrombin...
aspartate aminotransferase to form a complex, which can then bind to malate dehydrogenase, forming a ternarycomplex that reverses inhibitory action on...
Ternary complex of the WH2 domain of WASP with Actin-DNAse I 2a40: Ternarycomplex of the WH2 domain of WAVE with Actin-DNAse I 2a41: Ternarycomplex of the...
(via the α subunit), which is a part of the eIF2-GTP-Met-tRNAiMet ternarycomplex (eIF2-TC). When large numbers of eIF2 are phosphorylated, protein synthesis...
Andersen OA, Flatmark T, Hough E (July 2002). "Crystal structure of the ternarycomplex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin...
in more than 2 decades. As an rFVIIa product, eptacog beta works in a complex with tissue factor to activate factor X to Xa, thereby bypassing FVIII...
pre-miRNA is known as the ternarycomplex. Once the ternarycomplex is formed, it diffuses through a nuclear pore complex into the cytoplasm, transporting...
mechanism stimulation of thrombin inhibition depends on the formation of a ternarycomplex between AT-III, thrombin, and heparin. Increased Factor IXa and Xa...
linker must all be considered for PROTAC development. Formation of a ternarycomplex between the protein of interest, PROTAC, and E3 ligase may be evaluated...
following conventionally accepted mechanism. Based on the Extended Ternarycomplex model, the mechanism contends that inverse agonists switch the receptor...
peptide and the B2M subunit are normally required to maintain a stable ternarycomplex between the peptide, MHC I, and B2M, under subphysiological temperatures...
structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0...
A cyclin forms a complex with Cdk, which begins to activate but the complete activation requires phosphorylation, as well. Complex formation results...
the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation...
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