Telomeres in the cell cycle information

Telomeres, the caps on the ends of eukaryotic chromosomes, play critical roles in cellular aging and cancer. An important facet to how telomeres function...

Cell division is the process by which a parent cell divides into two daughter cells. Cell division usually occurs as part of a larger cell cycle in which...

diseases. Telomeres are DNA tandem repeats at the end of chromosomes that shorten during each cycle of cell division. Recently, the role of telomeres in cellular...

the cell division cycle. Therefore, telomeres act as the buffer for cells to continue dividing and when telomeres are worn out, cells lose their dividing...

restores telomeres, to protect their DNA and extend their cell division limit (the Hayflick limit). Potency specifies the differentiation potential (the potential...

(February 2006). "Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres". Molecular Biology of the Cell. 17 (2): 944–954...

TIN2, and TPP1. They can operate in smaller subsets to regulate the length of or to protect telomeres. In the cells of mice and humans, TRF1, TRF2, TIN2...

that are not subject to the Hayflick limit, the point at which cells can no longer divide due to DNA damage or shortened telomeres. Prior to Leonard Hayflick's...

senescence, so the cell stops dividing. Cancer cells bypass this barrier by manipulating enzymes (telomerase) to increase the length of telomeres. Thus, they...

cancer cells, and when knocked down, hnRNP reduced both cell viability and invasiveness. Several hnRNPs interact with telomeres, which protect the ends...

used to extend the cancer cell's life span. While the telomeres of most cells shorten after each division, eventually causing the cell to die, telomerase...

The G0 phase describes a cellular state outside of the replicative cell cycle. Classically[when?], cells were thought to enter G0 primarily due to environmental...

packages called telomeres that prevent DNA repair activities. Telomeres and mitotic DSBs have different functionality, but both experience the same 5′–3′ degradation...

cancerous cells. To be specific, TERT is responsible for catalyzing the addition of nucleotides in a TTAGGG sequence to the ends of a chromosome's telomeres. This...

meeting the criteria of not accumulating in areas beside chromosome ends, their function is limited to telomeres, and they are present at telomeres throughout...

as the original parent cell. The two meiotic divisions are known as meiosis I and meiosis II. Before meiosis begins, during S phase of the cell cycle, the...

Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. 25 (3): 347–52. doi:10...

of telomeres to protect DNA, though they are not foolproof: Streptomyces has telomeres capped by proteins, yet is known to represent "one of the most...

catastrophic telomere loss during DNA replication. In a normal cell, the telomeres (the ends of chromosomes) undergo repeated shortening during the cell cycle, which...

cell undergoes mitosis, the telomeres on the ends of each chromosome shorten slightly. Cell division will cease once telomeres shorten to a critical length...

alternative lengthening of telomeres (ALT). This recombination has been shown to require the accumulation of SLX4IP at ALT telomeres due to its antagonization...

The cell nucleus (from Latin nucleus or nuculeus 'kernel, seed'; pl.: nuclei) is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells...

split and dies. Telomerase is an enzyme which rebuilds the telomeres in stem cells and cancer cells, allowing them to replicate an infinite number of times...

Shortening of the telomeres is a normal process in somatic cells. This shortens the telomeres of the daughter DNA chromosome. As a result, cells can only divide...