Natural stoppage of cell cycle during cell division
Cell cycle withdrawal refers to the natural stoppage of cell cycle during cell division. When cells divide, there are many internal or external factors that would lead to a stoppage of division. This stoppage could be permanent or temporary, and could occur in any one of the four cycle phases (G1, S, G2 and M), depending on the status of cells or the activities they are undergoing.[1] During the process, all cell duplication process, including mitosis, meiosis as well as DNA replication, will be paused.[2] The mechanisms involve the proteins and DNA sequences inside cells.
^Yang, Lihui; Baker, Nicholas E. (2003). "Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye". Developmental Cell. 4 (3): 359–369. doi:10.1016/s1534-5807(03)00059-5. ISSN 1534-5807. PMID 12636917.
^Gooderham, Nigel J.; Zhu, Huijun (2006-05-01). "Mechanisms of Induction of Cell Cycle Arrest and Cell Death by Cryptolepine in Human Lung Adenocarcinoma A549 Cells". Toxicological Sciences. 91 (1): 132–139. doi:10.1093/toxsci/kfj146. ISSN 1096-6080. PMID 16510557.
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