Schematic representation of a niosome prepared by sorbitan monostearate (Span-60)[1]
Niosomes are vesicles composed of non-ionic surfactants, incorporating cholesterol as an excipient.[1] Niosomes are utilized for drug delivery to specific sites to achieve desired therapeutic effects.[2] Structurally, niosomes are similar to liposomes as both consist of a lipid bilayer. However, niosomes are more stable than liposomes during formation processes and storage.[3] Niosomes trap hydrophilic and lipophilic drugs, either in an aqueous compartment (for hydrophilic drugs)[4] or in a vesicular membrane compartment composed of lipid material (for lipophilic drugs).[3]
^ abMoghassemi S, Hadjizadeh A (July 2014). "Nano-niosomes as nanoscale drug delivery systems: an illustrated review". Journal of Controlled Release. 185: 22–36. doi:10.1016/j.jconrel.2014.04.015. PMID 24747765.
^"Drug Delivery Systems (definition)". www.reference.md. Retrieved 2021-04-20.
^ abGe X, Wei M, He S, Yuan WE (January 2019). "Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery". Pharmaceutics. 11 (2): 55. doi:10.3390/pharmaceutics11020055. PMC 6410054. PMID 30700021.
^Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K (October 2010). "Niosome: A future of targeted drug delivery systems". Journal of Advanced Pharmaceutical Technology & Research. 1 (4): 374–380. doi:10.4103/0110-5558.76435. PMC 3255404. PMID 22247876.
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