TNNT3 information

TNNT3
Identifiers
Aliases	TNNT3, TNTF, troponin T3, fast skeletal type, beta-TnTF, DA2B2
External IDs	OMIM: 600692 MGI: 109550 HomoloGene: 31405 GeneCards: TNNT3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,938,706 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	142,516,009 bp
RNA expression pattern
	Top expressed in
	skeletal muscle tissue; ; gastrocnemius muscle; ; left ventricle; ; placenta; ; right uterine tube; ; subcutaneous adipose tissue; ; Achilles tendon; ; left uterine tube; ; urinary bladder; ; vagina;
	Top expressed in
	sternocleidomastoid muscle; ; temporal muscle; ; digastric muscle; ; triceps brachii muscle; ; extensor digitorum longus muscle; ; plantaris muscle; ; tibialis anterior muscle; ; triceps surae; ; extraocular muscle; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-dependent ATPase activity; actin binding; tropomyosin binding; troponin I binding; calcium-dependent protein binding; troponin C binding; calcium ion binding; protein binding;
Cellular component	cytosol; troponin complex;
Biological process	regulation of muscle contraction; skeletal muscle contraction; regulation of striated muscle contraction; regulation of ATP-dependent activity; muscle filament sliding; muscle contraction; sarcomere organization; cardiac muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7140
	21957
	ENSG00000130595; ENSG00000288250
	ENSMUSG00000061723
	P45378
	Q9QZ47
NM_001042780; NM_001042781; NM_001042782; NM_001297646; NM_006757;
	NM_001363561; NM_001367842; NM_001367843; NM_001367844; NM_001367845; NM_001367846; NM_001367847; NM_001367848; NM_001367849; NM_001367850; NM_001367851; NM_001367852
NM_001163664; NM_001163665; NM_001163666; NM_001163667; NM_001163668;
	NM_001163669; NM_001163670; NM_011620; NM_001347546; NM_001347547; NM_001347548; NM_001347549; NM_001347550; NM_001347551; NM_001347552; NM_001360157; NM_001360158
NP_001036245; NP_001036246; NP_001036247; NP_001284575; NP_006748;
	NP_001350490; NP_001354771; NP_001354772; NP_001354773; NP_001354774; NP_001354775; NP_001354776; NP_001354777; NP_001354778; NP_001354779; NP_001354780; NP_001354781
NP_001157136; NP_001157137; NP_001157138; NP_001157139; NP_001157140;
	NP_001157141; NP_001157142; NP_001334475; NP_001334476; NP_001334477; NP_001334478; NP_001334479; NP_001334480; NP_001334481; NP_035750; NP_001347086; NP_001347087
	Wikidata
View/Edit Human	View/Edit Mouse

Fast skeletal muscle troponin T (fTnT) is a protein that in humans is encoded by the TNNT3 gene.^[5]^[6]

The TNNT3 gene is located at 11p15.5 in the human genome, encoding the fast skeletal muscle isoform of troponin T (fsTnT). fsTnT is an ~31-kDa protein consisting of 268 amino acids including the first methionine with an isoelectric point (pI) of 6.21 (embryonic form). fsTnT is the tropomyosin-binding and thin filament anchoring subunit of the troponin complex in the sarcomeres of fast twitch skeletal muscle.^[7]^[8]^[9] TNNT3 gene is specifically expressed in vertebrate fast twitch skeletal muscles.^[8]^[9]^[10]

^ ^a ^b ^c ENSG00000288250 GRCh38: Ensembl release 89: ENSG00000130595, ENSG00000288250 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061723 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference Wu_1993 was invoked but never defined (see the help page).
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Cite error: The named reference Perry_1998 was invoked but never defined (see the help page).
^ ^a ^b Cite error: The named reference Jin_2008 was invoked but never defined (see the help page).
^ ^a ^b Cite error: The named reference Wei_2011 was invoked but never defined (see the help page).
^ Cite error: The named reference Wu_1994 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] ENSG00000288250 GRCh38: Ensembl release 89: ENSG00000130595, ENSG00000288250 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061723 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Wu_1993-5] Cite error: The named reference Wu_1993 was invoked but never defined (see the help page).

[entrez-6] Cite error: The named reference entrez was invoked but never defined (see the help page).

[Perry_1998-7] Cite error: The named reference Perry_1998 was invoked but never defined (see the help page).

[Jin_2008-8] Cite error: The named reference Jin_2008 was invoked but never defined (see the help page).

[Wei_2011-9] Cite error: The named reference Wei_2011 was invoked but never defined (see the help page).

[Wu_1994-10] Cite error: The named reference Wu_1994 was invoked but never defined (see the help page).

TNNT3 information

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