TNNI1 information

TNNI1
Identifiers
Aliases	TNNI1, SSTNI, TNN1, troponin I1, slow skeletal type
External IDs	OMIM: 191042 MGI: 105073 HomoloGene: 2462 GeneCards: TNNI1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	201,429,866 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,738,727 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; thoracic diaphragm; ; vastus lateralis muscle; ; gastrocnemius muscle; ; body of tongue; ; deltoid muscle; ; tibialis anterior muscle; ; superior surface of tongue; ; left ventricle; ; trabecular bone;
	Top expressed in
	soleus muscle; ; atrium; ; endocardial cushion; ; atrioventricular valve; ; ankle; ; plantaris muscle; ; extraocular muscle; ; thoracic diaphragm; ; intercostal muscle; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; metal ion binding;
Cellular component	cytosol; troponin complex;
Biological process	ventricular cardiac muscle tissue morphogenesis; skeletal muscle contraction; regulation of striated muscle contraction; cardiac muscle contraction; transition between fast and slow fiber; muscle filament sliding; muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7135
	21952
	ENSG00000159173
	ENSMUSG00000026418
	P19237
	Q9WUZ5
	NM_003281
	NM_001112702; NM_021467
	NP_003272
	NP_001106173; NP_067442
	Wikidata
View/Edit Human	View/Edit Mouse

Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene.^[5]^[6]^[7] It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex.

Gene TNNI1, troponin I type 1 (skeletal muscle, slow), also known as TNN1 and SSTNI, is located at 1q31.3 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin I (ssTnI), the inhibitory subunit of the troponin complex in striated muscle myofilaments.^[8]^[9] Human TNNI1 spans 12.5 kilobases in the genomic DNA and contains 9 exons and 8 introns.^[6] Exon 2 to exon 8 contain the coding sequences, encoding a protein of 21.7 kDa consisting of 187 amino acids including the first methionine with an isoelectric point (pI) of 9.59.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159173 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wade R, Eddy R, Shows TB, Kedes L (Jul 1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I". Genomics. 7 (3): 346–57. doi:10.1016/0888-7543(90)90168-T. PMID 2365354.
^ ^a ^b Corin SJ, Juhasz O, Zhu L, Conley P, Kedes L, Wade R (Apr 1994). "Structure and expression of the human slow twitch skeletal muscle troponin I gene". The Journal of Biological Chemistry. 269 (14): 10651–9. doi:10.1016/S0021-9258(17)34109-1. PMID 8144655.
^ "Entrez Gene: TNNI1 troponin I type 1 (skeletal, slow)".
^ Perry SV (Jan 1999). "Troponin I: inhibitor or facilitator". Molecular and Cellular Biochemistry. 190 (1–2): 9–32. doi:10.1023/A:1006939307715. PMID 10098965. S2CID 23721684.
^ Jin JP, Zhang Z, Bautista JA (2008). "Isoform diversity, regulation, and functional adaptation of troponin and calponin". Critical Reviews in Eukaryotic Gene Expression. 18 (2): 93–124. doi:10.1615/critreveukargeneexpr.v18.i2.10. PMID 18304026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159173 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026418 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2365354-5] Wade R, Eddy R, Shows TB, Kedes L (Jul 1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I". Genomics. 7 (3): 346–57. doi:10.1016/0888-7543(90)90168-T. PMID 2365354.

[pmid8144655-6] Corin SJ, Juhasz O, Zhu L, Conley P, Kedes L, Wade R (Apr 1994). "Structure and expression of the human slow twitch skeletal muscle troponin I gene". The Journal of Biological Chemistry. 269 (14): 10651–9. doi:10.1016/S0021-9258(17)34109-1. PMID 8144655.

[entrez-7] "Entrez Gene: TNNI1 troponin I type 1 (skeletal, slow)".

[Perry_1999-8] Perry SV (Jan 1999). "Troponin I: inhibitor or facilitator". Molecular and Cellular Biochemistry. 190 (1–2): 9–32. doi:10.1023/A:1006939307715. PMID 10098965. S2CID 23721684.

[9] Jin JP, Zhang Z, Bautista JA (2008). "Isoform diversity, regulation, and functional adaptation of troponin and calponin". Critical Reviews in Eukaryotic Gene Expression. 18 (2): 93–124. doi:10.1615/critreveukargeneexpr.v18.i2.10. PMID 18304026.

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