Slow skeletal muscle troponin T (sTnT) is a protein that in humans is encoded by the TNNT1 gene.[5][6]
The TNNT1 gene is located at 19q13.4 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin T (ssTnT). ssTnT is an ~32-kDa protein consisting of 262 amino acids (including the first methionine) with an isoelectric point (pI) of 5.95. It is the tropomyosin binding and thin filament anchoring subunit of the troponin complex in the sarcomeres of slow twitch skeletal muscle fibers.[7][8][9] TNNT1 gene is specifically expressed in slow skeletal muscle of vertebrates, with one exception that dry land toad (Bufo) cardiac muscle expresses ssTnT other than cardiac TnT.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000105048 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000064179 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cite error: The named reference Samson_1992 was invoked but never defined (see the help page).
^"Entrez Gene: TNNT1 troponin T type 1 (skeletal, slow)".
^Cite error: The named reference Perry_1998 was invoked but never defined (see the help page).
^Cite error: The named reference Jin_2008 was invoked but never defined (see the help page).
^Cite error: The named reference Wei_2011 was invoked but never defined (see the help page).
^Cite error: The named reference Feng_2012 was invoked but never defined (see the help page).
troponin T (sTnT) is a protein that in humans is encoded by the TNNT1 gene. The TNNT1 gene is located at 19q13.4 in the human chromosomal genome, encoding...
Heidelberg, who also developed the troponin T assay. Slow skeletal troponin T1, TNNT1 (19q13.4, 191041) Cardiac troponin T2, TNNT2 (1q32, 191045) Fast skeletal...
published in Gene and can be cited as: Wei B, Jin JP (13 January 2016). "TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships"...
significantly diverged from the slow skeletal muscle TnT (ssTnT encoded by TNNT1) and cardiac TnT (cTnT encoded by TNNT2), Structure of fsTnT is conserved...
PRKG1 has been shown to interact with: GTF2I, ITPR1, MRVI1, RGS2, and TNNT1. GRCh38: Ensembl release 89: ENSG00000185532 – Ensembl, May 2017 GRCm38:...
interacts with SMAD3, MBD3L2, Q494R0, SNRNP35, A8MTQ0, AIMP2, DMAP1, EXOSC2, TNNT1, GATAD2B, and Q8WUT1. SMAD3 is a receptor-regulated subtype of SMAD, which...
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