substrate-dependent cell migration, cell attachment to substrate
multicellular organism development
positive regulation of extrinsic apoptotic signaling pathway
cell differentiation
positive regulation of axon extension
cell adhesion
tumor necrosis factor-mediated signaling pathway
regulation of wound healing
regulation of angiogenesis
extrinsic apoptotic signaling pathway
angiogenesis
positive regulation of apoptotic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51330
27279
Ensembl
ENSG00000006327
ENSMUSG00000023905
UniProt
Q9NP84
Q9CR75
RefSeq (mRNA)
NM_016639
NM_001161746 NM_013749
RefSeq (protein)
NP_057723
NP_001155218 NP_038777
Location (UCSC)
Chr 16: 3.02 – 3.02 Mb
Chr 17: 23.89 – 23.9 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.[5][6][7]
Other names used when talking about TNFRSF12A are fibroblast growth factor-inducible immediate-early response protein 14 (FN14).[8] TNFRSF12A is a unique member of the Tumor Necrosis Factor Receptor superfamily. TNFRSF12A is the smallest member of the Tumor Necrosis Factor Receptor superfamily[8] and the gene expression is highly regulated in a live organism and a petri dish.[9] TNFRSF12A is the receptor for the TWEAK which is its ligand.[8] Many other members of the Tumor necrosis factor superfamily can bind to other ligands but this receptor can only bind to TNFRSF12.[10] TNFRSF12A is found in many human tissues, including the heart, placenta, lung, skeletal muscle, kidney, and pancreas. It is involved in several biological processes, such as inflammatory reactions, angiogenesis, cell proliferation, and cell death.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000006327 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023905 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, et al. (April 2000). "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas". The American Journal of Pathology. 156 (4): 1253–1261. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.
^Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, et al. (November 1999). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". The Journal of Biological Chemistry. 274 (46): 33166–33176. doi:10.1074/jbc.274.46.33166. PMID 10551889.
^"Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".
^ abcWinkles JA (May 2008). "The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting". Nature Reviews. Drug Discovery. 7 (5): 411–425. doi:10.1038/nrd2488. PMC 3018765. PMID 18404150.
^Cite error: The named reference Ruiz_2023 was invoked but never defined (see the help page).
^Perez JG, Tran NL, Rosenblum MG, Schneider CS, Connolly NP, Kim AJ, et al. (April 2016). "The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics". Oncogene. 35 (17): 2145–2155. doi:10.1038/onc.2015.310. PMC 4850525. PMID 26300004.
^Cite error: The named reference Liao_2023 was invoked but never defined (see the help page).
a protein that in humans is encoded by the TNFRSF12A gene. Other names used when talking about TNFRSF12A are fibroblast growth factor-inducible immediate-early...
development, thermal regulation, and mammary gland development CD266 TNFRSF12A (Tumor necrosis factor receptor superfamily member 12A), or Tweak-receptor...
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