TIMP3 information

TIMP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CKI
Identifiers
Aliases	TIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
External IDs	OMIM: 188826; MGI: 98754; HomoloGene: 36322; GeneCards: TIMP3; OMA:TIMP3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	32,863,041 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	86,185,370 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; decidua; ; retinal pigment epithelium; ; urethra; ; right lung; ; lower lobe of lung; ; vena cava; ; saphenous vein; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	retinal pigment epithelium; ; right kidney; ; ciliary body; ; right lung; ; human kidney; ; right lung lobe; ; carotid body; ; aortic valve; ; skin of external ear; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metal ion binding; protease binding; protein binding; metalloendopeptidase inhibitor activity;
Cellular component	extracellular matrix; basement membrane; extracellular exosome; nucleus; extracellular region; platelet dense granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	cellular response to organic substance; negative regulation of peptidase activity; response to stimulus; positive regulation of TRAIL-activated apoptotic signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; visual perception; platelet degranulation; response to organic substance; negative regulation of metalloendopeptidase activity; response to hormone; negative regulation of endopeptidase activity; response to cytokine;
	Sources:Amigo / QuickGO
Orthologs
	7078
	21859
	ENSG00000100234
	ENSMUSG00000020044
	P35625
	P39876
	NM_000362
	NM_011595
	NP_000353
	NP_035725
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.^[5]^[6]

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100234 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020044 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Apte SS, Mattei MG, Olsen BR (Jun 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22". Genomics. 19 (1): 86–90. doi:10.1006/geno.1994.1016. PMID 8188246.
^ Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med. 9 (4): 407–15. doi:10.1038/nm846. PMID 12652295. S2CID 12563403.
^ "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100234 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020044 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8188246-5] Apte SS, Mattei MG, Olsen BR (Jun 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22". Genomics. 19 (1): 86–90. doi:10.1006/geno.1994.1016. PMID 8188246.

[pmid12652295-6] Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med. 9 (4): 407–15. doi:10.1038/nm846. PMID 12652295. S2CID 12563403.

[7] "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)".

TIMP3 information

and 19 Related for: TIMP3 information

TIMP3

Tissue inhibitor of metalloproteinase

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Epigenetic priming

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Proteases in angiogenesis

List of OMIM disorder codes

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