negative regulation of membrane protein ectodomain proteolysis
negative regulation of catalytic activity
negative regulation of endopeptidase activity
response to hormone
response to cytokine
biological process
response to organic substance
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7079
110595
Ensembl
ENSG00000157150
ENSMUSG00000030317
UniProt
Q99727
Q9JHB3
RefSeq (mRNA)
NM_003256
NM_080639 NM_001356406
RefSeq (protein)
NP_003247
NP_542370 NP_001343335
Location (UCSC)
Chr 3: 12.15 – 12.16 Mb
Chr 6: 115.22 – 115.23 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.[5][6][7]
This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000157150 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030317 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Greene J, Wang M, Liu YE, Raymond LA, Rosen C, Shi YE (Jan 1997). "Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4". J Biol Chem. 271 (48): 30375–30380. doi:10.1074/jbc.271.48.30375. PMID 8939999.
^Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998). "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively". Genomics. 51 (1): 148–151. doi:10.1006/geno.1998.5362. PMID 9693046.
^ ab"Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4".
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. This gene belongs to the tissue inhibitor of metalloproteinases gene...
matrix metalloproteinases. There are four TIMPs; TIMP1, TIMP2, TIMP3 and TIMP4. TIMP3 has been observed progressively downregulated in Human papillomavirus-positive...
various tumors, such as laryngeal carcinoma or melanoma. TIMP2, TIMP3, TIMP4 GRCh38: Ensembl release 89: ENSG00000102265 – Ensembl, May 2017 GRCm38:...
and metastasis. MMP2 has been shown to interact with: CCL7, THBS2, TIMP2, TIMP4, and Thrombospondin 1. GRCh38: Ensembl release 89: ENSG00000087245 – Ensembl...
plasticity. TIMP2 has been shown to interact with: MMP14 and MMP2. TIMP1, TIMP3, TIMP4 GRCh38: Ensembl release 89: ENSG00000035862 – Ensembl, May 2017 GRCm38:...