SULT1A3 information

SULT1A3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1CJM, 2A3R,%%s1CJM
Identifiers
Aliases	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST, ST1A3, sulfotransferase family 1A member 3, ST1A4
External IDs	OMIM: 600641; HomoloGene: 133085; GeneCards: SULT1A3; OMA:SULT1A3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,204,310 bp
RNA expression pattern
	Top expressed in
	duodenum; ; mucosa of transverse colon; ; granulocyte; ; right hemisphere of cerebellum; ; spleen; ; rectum; ; right lobe of liver; ; right lobe of thyroid gland; ; pituitary gland; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; protein binding; aryl sulfotransferase activity; sulfate binding; amine sulfotransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	steroid metabolic process; IRE1-mediated unfolded protein response; catecholamine metabolic process; sulfation; lipid metabolism; flavonoid metabolic process; xenobiotic metabolic process; ethanol catabolic process; dopamine receptor signaling pathway; dopamine catabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; ERK1 and ERK2 cascade; calcineurin-mediated signaling; NMDA selective glutamate receptor signaling pathway; negative regulation of neuron death; cellular response to dopamine;
	Sources:Amigo / QuickGO
Orthologs
	6818
	n/a
	ENSG00000261052
	n/a
	P0DMM9; P0DMN0
	n/a
	NM_001017387; NM_003166; NM_177552
	n/a
	NP_808220; NP_001017390; NP_001017390.1; NP_808220.1; NP_001017390
	n/a
	Wikidata
View/Edit Human

Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.^[3]^[4]^[5]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Three alternatively spliced variants that encode the same protein have been described.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000261052 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wood TC, Aksoy IA, Aksoy S, Weinshilboum RM (Mar 1994). "Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization". Biochem Biophys Res Commun. 198 (3): 1119–27. doi:10.1006/bbrc.1994.1159. PMID 8117269.
^ Aksoy IA, Callen DF, Apostolou S, Her C, Weinshilboum RM (Feb 1995). "Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2". Genomics. 23 (1): 275–7. doi:10.1006/geno.1994.1494. PMID 7829089.
^ ^a ^b "Entrez Gene: SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000261052 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8117269-3] Wood TC, Aksoy IA, Aksoy S, Weinshilboum RM (Mar 1994). "Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization". Biochem Biophys Res Commun. 198 (3): 1119–27. doi:10.1006/bbrc.1994.1159. PMID 8117269.

[pmid7829089-4] Aksoy IA, Callen DF, Apostolou S, Her C, Weinshilboum RM (Feb 1995). "Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2". Genomics. 23 (1): 275–7. doi:10.1006/geno.1994.1494. PMID 7829089.

[entrez-5] "Entrez Gene: SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3".

SULT1A3 information

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