Subacute combined degeneration of spinal cord information
Medical condition
Subacute combined degeneration of spinal cord
Diagram of the principal fasciculi of the spinal cord. (In subacute combined degeneration of spinal cord, the "combined" refers to the fact that the dorsal columns and lateral corticospinal tracts are both affected, in contrast to tabes dorsalis which is selective for the dorsal columns.)
Specialty
Neurology
Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis,[1] also Lichtheim's disease,[2][3] and Putnam-Dana syndrome,[4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B12 deficiency (most common). It may also occur similarly as result of vitamin E deficiency,[5] and copper deficiency.[6] It is usually associated with pernicious anemia.
^Tsoriev A. "Subacute combined degeneration of the cord (funicular myelosis) | Radiology Case | Radiopaedia.org". Radiopaedia. Retrieved 5 February 2022.
^synd/492 at Who Named It?
^L. Lichtheim. Zur Kenntnis der perniciösen Anämie. Verhandlungen des Deutschen Kongress für innere Medizin, 1889, 6: 84-96. 42: 1887.
^Pearce JM (June 2008). "Subacute combined degeneration of the cord: Putnam-Dana syndrome". European Neurology. 60 (1): 53–56. doi:10.1159/000131715. PMID 18520150.
^Agamanolis DP (July 2014). "Nutritional CNS Disorders". Retrieved 13 September 2014. Clinically, vitamin E deficiency causes a sensory peripheral neuropathy, ataxia, retinitis pigmentosa, and skeletal and cardiac myopathy. Neuropathological examination in such cases reveals loss of dorsal ganglionic neurons with degeneration of their peripheral and central axons (peripheral neuropathy and posterior column degeneration respectively). Neuroaxonal swellings are seen in the gracile and cuneate nuclei. Similar changes can be produced in rats and monkeys with experimental vitamin E deprivation.
^Kumar N, Gross JB, Ahlskog JE (July 2004). "Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration". Neurology. 63 (1): 33–39. doi:10.1212/01.WNL.0000132644.52613.FA. PMID 15249607. S2CID 37568461.
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of peripheral sensory-motor symptoms or subacutecombineddegenerationofspinalcord strongly suggests the presence of a B12 deficiency instead of folate...
congestive heart failure. A complication of severe chronic PA is subacutecombineddegenerationofspinalcord, which leads to distal sensory loss (posterior...
nerve damage if the condition is not diagnosed quickly. Subacutecombineddegenerationofspinalcord secondary to pernicious anaemia can lead to slight peripheral...
Vitamin deficiency is the condition of a long-term lack of a vitamin. When caused by not enough vitamin intake it is classified as a primary deficiency...
have been reports of sulfuric acid ingestion leading to vitamin B12 deficiency with subacutecombineddegeneration. The spinalcord is most often affected...
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serves as a source of "CH3+". A lack of cobalamin can lead to megaloblastic anemia and subacutecombineddegenerationof the spinalcord. Cobamamide Cyanocobalamin...
combined degeneration (SCD). Subacutecombineddegeneration is also a degenerationof the spinalcord, but instead vitamin B12 deficiency is the cause of the...
originate from lesions of the cortex, subcortex or spinalcord. The presence of myoclonus above the foramen magnum effectively excludes spinal myoclonus; further...
as night-shift work and lack of physical activity can also increase the risk of lumbar disc disease. Severe spinal-cord compression is considered a surgical...
Pathology of the Gastrointestinal Tract in Pernicious Anemia and SubacuteCombinedDegenerationof the SpinalCord" (1934) "The Medical Treatment of Ménière's...
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Fellow of the Royal College of Physicians (FRCP) in 1897. In 1900, he wrote the pioneer description ofsubacutecombineddegenerationof the spinalcord with...
combined degeneration (SCD). Subacutecombineddegeneration is also a degenerationof the spinalcord, but instead vitamin B12 deficiency is the cause of the...
may occur in some instances of the disease. Anaemia may in turn result in subacutecombineddegenerationof the spinalcord and cognitive decline. D. latum...
Royal College of Physicians. Ungley, C. C.; Suzman, M. M. (1929). "Subacutecombineddegenerationof the cord: symptomatology and effects of liver therapy"...
most esteemed work is his comprehensive analysis ofSubacutecombineddegenerationof the spinalcord, ... written in 1900 in collaboration with JSR Russell...
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