Complex of catalytic domain of human plasmin and streptokinase
Clinical data
Other names
SK
AHFS/Drugs.com
Micromedex Detailed Consumer Information
Routes of administration
Intravenous
ATC code
B01AD01 (WHO)
Identifiers
CAS Number
9002-01-1
DrugBank
DB00086
ChemSpider
none
UNII
8X1OXL3SNU
ECHA InfoCard
100.029.667
Chemical and physical data
Formula
C2100H3278N566O669S4
Molar mass
47286.86 g·mol−1
Streptokinase is a thrombolytic medication activating plasminogen by nonenzymatic mechanism.[1] As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism.[2] The type of heart attack it is used in is an ST elevation myocardial infarction (STEMI).[3] It is given by injection into a vein.[2]
Side effects include nausea, bleeding, low blood pressure, and allergic reactions.[2] A second use in a person's lifetime is not recommended.[2] While no harm has been found with use in pregnancy, it has not been well studied in this group.[4] Streptokinase is in the antithrombotic family of medications and works by turning on the fibrinolytic system.[3]
Streptokinase was discovered in 1933 from beta-hemolytic streptococci.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is no longer commercially available in the United States.[7]
^Mican J, Toul M, Bednar D, Damborsky J (2019). "Structural Biology and Protein Engineering of Thrombolytics". Computational and Structural Biotechnology Journal. 17: 917–938. doi:10.1016/j.csbj.2019.06.023. PMC 6637190. PMID 31360331.
^ abcdWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 291–2. hdl:10665/44053. ISBN 9789241547659.
^ ab"Streptokinase 1,500,000 iu - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 1 July 2015. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
^"Streptokinase Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 14 December 2016.
^Sikri N, Bardia A (2007). "A history of streptokinase use in acute myocardial infarction". Texas Heart Institute Journal. 34 (3): 318–327. PMC 1995058. PMID 17948083.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"streptokinase (Intravenous route, Intracoronary route)". Truven Health Analytics. Archived from the original on 8 December 2015. Retrieved 28 November 2015.
Streptokinase is a thrombolytic medication activating plasminogen by nonenzymatic mechanism. As a medication it is used to break down clots in some cases...
is a thrombolytic drug. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC). As a thrombolytic drug, it is used to treat...
Hg) Puncture of noncompressible blood vessel within 2 weeks Previous streptokinase therapy Major surgery, trauma, or bleeding within 2 weeks Absolute contraindications:...
required. Below-knee and above-knee amputation is rarely required. Streptokinase has been proposed as adjuvant therapy in some cases. Despite the clear...
These medications include tissue plasminogen activator, reteplase, streptokinase, and tenecteplase. Thrombolysis is not recommended in a number of situations...
other drugs can be used to promote thrombolysis or clot breakdown. Streptokinase, an enzyme produced by streptococcal bacteria, is one of the oldest...
middle-income levels. Regarding MI, strategies using aspirin, atenolol, streptokinase or tissue plasminogen activator have been compared for quality-adjusted...
niger. Microorganisms are used to prepare bioactive molecules such as Streptokinase from the bacterium Streptococcus, Cyclosporin A from the ascomycete...
of the abdomen for a pistol shot wound. William Tillett discovered streptokinase, later used for the acute treatment of myocardial infarction, at Bellevue...
thrombolytic agent (e.g., recombinant tissue plasminogen activator (tPA), streptokinase, or urokinase). A percutaneous catheter inserted into the femoral artery...
antihemophilic factor VIII, interferon alfa, anti-blood clot medicine streptokinase, and wasp venom allergenic extract. Many bio-pharmaceutical products...
infarction caused by enhanced platelet activation leading to thrombosis. Streptokinase is a thrombolytic agent which aims to permit reperfusion, allowing the...
MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX 1l4z: X-RAY CRYSTAL STRUCTURE OF THE COMPLEX OF MICROPLASMINOGEN WITH ALPHA DOMAIN OF STREPTOKINASE IN THE PRESENCE...
channels, a family of ion channels Solar keratosis or senile keratosis Streptokinase, a bacterial enzyme used in the treatment of blood clots SK Gaming,...
VATS is unavailable, an alternative is fibrinolytic therapy such as streptokinase or urokinase given directly into the pleural space seven to ten days...
complement components, and immunoglobulins. Also called streptopain. Streptokinase Enzymatically activates plasminogen, a proteolytic enzyme, into plasmin...
and morbidity. It has been investigated for use in conjunction with streptokinase. One potential advantage of fondaparinux over LMWH or unfractionated...
FasX small RNA (fibronectin/fibrinogen-binding/haemolytic-activity/streptokinase-regulator-X) is a non-coding small RNA (sRNA) produced by all group...
secrete agents that alter the coagulation system, e.g. coagulase and streptokinase.[citation needed] Various substances are required for the proper functioning...
amylase, protease, pectinase, cellulase, hemicellulase, lipase, lactase, streptokinase and many others. Recombinant proteins, such as insulin, hepatitis B...
and mortality, including diuretic therapy, repeated lumbar puncture, streptokinase therapy and a combination novel intervention called DRIFT (drainage...
of blood clots that cannot be dissolved by other compounds, such as streptokinase and urokinase.[citation needed] The processes of blood anticoagulation...
1016/0006-2952(82)90652-9. PMID 6818974. "Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither Among 17,187 Cases of Suspected Acute...
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