Streptogramin A is a group of antibiotics within the larger family of antibiotics known as streptogramins. They are synthesized by the bacteria Streptomyces virginiae.[1] The streptogramin family of antibiotics consists of two distinct groups: group A antibiotics contain a 23-membered unsaturated ring with lactone and peptide bonds while group B antibiotics are depsipeptides (lactone-cyclized peptides). While structurally different, these two groups of antibiotics act synergistically, providing greater antibiotic activity than the combined activity of the separate components. These antibiotics have until recently been commercially manufactured as feed additives in agriculture, although today there is increased interest in their ability to combat antibiotic-resistant bacteria, particularly vancomycin-resistant bacteria.[2]
^"KEGG COMPOUND: C11299". www.genome.jp.
^Mukhtar, T. A.; Wright, G.D. (2005). "Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis". Chem. Rev. 105 (2): 529–542. CiteSeerX 10.1.1.460.6691. doi:10.1021/cr030110z. PMID 15700955.
Streptogramins are a class of antibiotics. Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant...
StreptograminA is a group of antibiotics within the larger family of antibiotics known as streptogramins. They are synthesized by the bacteria Streptomyces...
Streptogramin B is a subgroup of the streptogramin antibiotics family. These natural products are cyclic hexa- or hepta depsipeptides produced by various...
replication in a bacteriostatic mechanism by interfering with the synthesis of proteins. In a mechanism similar to macrolides and streptogramin B, lincosamides...
treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is astreptogramin group antibiotic, similar to virginiamycin...
This phenotype of bacteria are resistant to the macrolide-lincosamide-streptogramin B group of antibiotics, however, the resistance mechanism is only induced...
list (link) The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome Martin Lovmar...
against vancomycin-resistant Enterococcus (VRE): Linezolid and Tedizolid Streptogramins such as quinupristin-dalfopristin Advanced generation tetracyclines:...
Moellering RC (March 1993). "In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms". Antimicrobial...
Dalfopristin is a semi-synthetic streptogramin antibiotic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptograminA). The combination...
Quinupristin is astreptogramin B antibiotic, used in combination with dalfopristin under the trade name Synercid. It has activity against Gram-positive...
Antibacterials for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed...
quickly dissociates from the ribosome, causing a premature termination of polypeptide synthesis. Streptogramins also cause premature release of the peptide...
mutation, and results in cross-resistance to macrolides, lincosamides, and streptogramins (an MLS-resistant phenotype). Two other forms of acquired resistance...
Virginiamycin is astreptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA (virginiamycin...
Pristinamycin IA (Mikamycin B) is an antibiotic cyclic peptide. It is a member of the streptogramin B group of antibiotics and one component of pristinamycin (the...
Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptograminA group of antibiotics and one component of pristinamycin (the other...
Xerava) is a synthetic halogenated tetracycline class antibiotic by Tetraphase Pharmaceuticals. It is closely related to tigecycline. It has a broad spectrum...
entirely tolerant of alcohol. Linezolid, daptomycin, tigecycline and the streptogramins (e.g. quinupristin/dalfopristin) can have activity against VRE. VRE...
Virginiamycin S1 is a macrolide antibiotic in the group of antibiotics known as streptogramin B. Kingston, David G. I.; Molinero, Anthony A.; Purvis, Michael...
1016/0304-4165(65)90121-2. PMID 14292864. Haste, Nina M (2010). "Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus"...
Flopristin is a semi-synthetic antibiotic of the streptograminA class. It is a fluorinated derivative of pristinamycin IIB.[citation needed] Flopristin...
azithromycin), lincosamides (specifically lincomycin and clindamycin), streptogramins, rifampicin, fusidic acid, and fosfomycin. P. gergoviae is also resistant...
an antibiotic of the streptogramin B class. It is one of the components of the antibiotic combination NXL103. Pankuch, Glenn A.; Kelly, Linda M.; Lin...
Fenical, William; Nizet, Victor; Hensler, Mary E (2010). "Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus"...
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