Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being pristinamycin IA).[1] Pristinamycin IIA was first isolated from the Streptomyces virginiae, but has been isolated from other microorganisms and thus has been given a variety of other names such as Virginiamycin M1, Mikamycin A, and Streptogramin A.[2] Pristinamycin IIA structure was determined by chemical and instrumental techniques, including X-ray crystallography.[2][3] Pristinamycin IIA is of interest from a biosynthetic viewpoint because it contains the unusual dehydroproline and oxazole ring systems.[2] The only experimental evidence bearing on the formation of the oxazole ring is found in work on the biosynthesis of the alkaloid annuloline.[2][4]
^Laforest H, Fourgeaud M, Richet H, Lagrange PH (July 1988). "Comparative in vitro activities of pristinamycin, its components, and other antimicrobial agents against anaerobic bacteria". Antimicrobial Agents and Chemotherapy. 32 (7): 1094–1096. doi:10.1128/AAC.32.7.1094. PMC 172352. PMID 3142342.
^ abcd Kingston DG, Kolpak MX (August 1980). "Biosynthesis of antibiotics of the virginiamycin family. 1. Biosynthesis of virginiamycin M1: determination of the labeling pattern by the use of stable isotope techniques". Journal of the American Chemical Society. 102 (18): 5964–5966. doi:10.1021/ja00538a070. Retrieved 29 May 2022.
^ Delpierre GR, Eastwood FW, Gream GE, Kingston DG, Sarin PS, Todd L, Williams DH (1966). "Antibiotics of the ostreogrycin complex. II. Structure of ostreogrycin A". Journal of the Chemical Society, Perkin Transactions 1. 19: 1653–1669. doi:10.1039/j39660001653. PMID 5950461.
^ O'Donovan DG, Horan HJ (1971). "The biosynthesis of annuloline, a unique oxazole alkaloid". Journal of the Chemical Society C: Organic. 1: 331–334. doi:10.1039/J39710000331.
PristinamycinIIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being...
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