Class of natural cyclic peptide antibiotics produced by certain subspecies of Streptomyces
Streptogramins are a class of antibiotics.[1]
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A and streptogramin B.[citation needed]
Members include:
Quinupristin/dalfopristin
Pristinamycin
Virginiamycin
NXL 103, an experimental streptogramin in clinical trials for the treatment of respiratory tract infections.[2]
^University of Leeds: Antimicrobial Chemotherapy Archived 2007-04-28 at the Wayback Machine
^Boucher, H. W.; Talbot, G. H.; Bradley, J. S.; Edwards, J. E.; Gilbert, D; Rice, L. B.; Scheld, M; Spellberg, B; Bartlett, J (2009). "Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America". Clinical Infectious Diseases. 48 (1): 1–12. doi:10.1086/595011. PMID 19035777.
Streptogramins are a class of antibiotics. Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant...
Streptogramin A is a group of antibiotics within the larger family of antibiotics known as streptogramins. They are synthesized by the bacteria Streptomyces...
Streptogramin B is a subgroup of the streptogramin antibiotics family. These natural products are cyclic hexa- or hepta depsipeptides produced by various...
the synthesis of proteins. In a mechanism similar to macrolides and streptogramin B, lincosamides bind close to the peptidyl transferase center on the...
infections, and to a lesser extent streptococcal infections. It is a streptogramin group antibiotic, similar to virginiamycin, derived from the bacterium...
This phenotype of bacteria are resistant to the macrolide-lincosamide-streptogramin B group of antibiotics, however, the resistance mechanism is only induced...
Moellering RC (March 1993). "In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms". Antimicrobial...
list (link) The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome Martin Lovmar...
mutation, and results in cross-resistance to macrolides, lincosamides, and streptogramins (an MLS-resistant phenotype). Two other forms of acquired resistance...
Dalfopristin is a semi-synthetic streptogramin antibiotic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A). The combination...
against vancomycin-resistant Enterococcus (VRE): Linezolid and Tedizolid Streptogramins such as quinupristin-dalfopristin Advanced generation tetracyclines:...
ATC code J01 Antibacterials for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric...
Quinupristin is a streptogramin B antibiotic, used in combination with dalfopristin under the trade name Synercid. It has activity against Gram-positive...
Linopristin is an antibiotic of the streptogramin B class. It is one of the components of the antibiotic combination NXL103. Pankuch, Glenn A.; Kelly...
Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA (virginiamycin...
azithromycin), lincosamides (specifically lincomycin and clindamycin), streptogramins, rifampicin, fusidic acid, and fosfomycin. P. gergoviae is also resistant...
ribosome, causing a premature termination of polypeptide synthesis. Streptogramins also cause premature release of the peptide chain. Retapamulin Mupirocin...
entirely tolerant of alcohol. Linezolid, daptomycin, tigecycline and the streptogramins (e.g. quinupristin/dalfopristin) can have activity against VRE. VRE...
Virginiamycin S1 is a macrolide antibiotic in the group of antibiotics known as streptogramin B. Kingston, David G. I.; Molinero, Anthony A.; Purvis, Michael B.;...
(Mikamycin B) is an antibiotic cyclic peptide. It is a member of the streptogramin B group of antibiotics and one component of pristinamycin (the other...
Flopristin is a semi-synthetic antibiotic of the streptogramin A class. It is a fluorinated derivative of pristinamycin IIB.[citation needed] Flopristin...
Pristinamycin IIB is an antibiotic of the streptogramin A class. It was isolated from Streptomyces pristinaespiralis and its chemical structure was first...
clindamycin activity, the strains with inducible macrolide lincosamide-streptogramin type B (iMLSB) resistance, and strains with noninducible resistance...
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