The stem cell secretome (also referred to as the stromal cell secretome) is a collective term for the paracrine soluble factors produced by stem cells and utilized for their inter-cell communication. In addition to inter-cell communication, the paracrine factors are also responsible for tissue development, homeostasis and (re-)generation. The stem cell secretome consists of extracellular vesicles,[1] specifically exosomes, microvesicles, membrane particles, peptides and small proteins (cytokines). The paracrine activity of stem cells, i.e. the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and/or inflammatory diseases.[2] Though not only stem cells possess a secretome which influences their cellular environment, their secretome currently appears to be the most relevant for therapeutic use.[3]
^Teixeira, Fábio G.; Carvalho, Miguel M.; Sousa, Nuno; Salgado, António J. (2013-10-01). "Mesenchymal stem cells secretome: a new paradigm for a central nervous system regeneration?". Cellular and Molecular Life Sciences. 70 (20): 3871–3882. doi:10.1007/s00018-013-1290-8. hdl:1822/25128. ISSN 1420-682X. PMID 23456256. S2CID 18640402.
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Mahla RS (2016). "Stem cells application in regenerative medicine and disease threpeutics". International Journal of Cell Biology. 2016 (7): 1–24. doi:10.1155/2016/6940283. PMC 4969512. PMID 27516776.
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identified as being in the secretome by either or both of Uniprot or Exocarta, or else by studies investigating the secretome of muscle cells. Because many of the...
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S2CID 11583190. Hathout Y (April 2007). "Approaches to the study of the cellsecretome". Expert Review of Proteomics. 4 (2): 239–248. doi:10.1586/14789450...
metabolites and small RNAs are found in the secretome of skeletal muscles. A secretome is secreted by skeletal muscle cells, either locally (in skeletal muscle...
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phenotypes that contributes to "inflammaging." The secretome of senescent mesenchymal stem and stromal cells (MSCs) exhibits immunomodulatory effects and serves...
expression of inflammatory genes, with result profound change in the secretome and the cell phenotypes, their activity in the tumor, and their capacity for...
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