Predicted secondary structure and sequence conservation of SprX small RNA
Identifiers
Rfam
RF02672
Other data
Domain(s)
Bacteria
GO
GO:0040033
SO
SO:0000370
PDB structures
PDBe
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In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.[3]
^Bohn C, Rigoulay C, Chabelskaya S, Sharma CM, Marchais A, Skorski P, Borezée-Durant E, Barbet R, Jacquet E, Jacq A, Gautheret D, Felden B, Vogel J, Bouloc P (October 2010). "Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism". Nucleic Acids Research. 38 (19): 6620–36. doi:10.1093/nar/gkq462. PMC 2965222. PMID 20511587.
^Eyraud A, Tattevin P, Chabelskaya S, Felden B (April 2014). "A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus". Nucleic Acids Research. 42 (8): 4892–905. doi:10.1093/nar/gku149. PMC 4005690. PMID 24557948.
^Kathirvel M, Buchad H, Nair M (December 2016). "Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1". Medical Microbiology and Immunology. 205 (6): 563–574. doi:10.1007/s00430-016-0467-9. PMID 27438010. S2CID 15284645.
In molecular biology the small pathogenicity island RNAX (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis...
component 3 and IgG. Protein A SprX Chabelskaya S, Gaillot O, Felden B (June 2010). "A Staphylococcus aureus smallRNA is required for bacterial virulence...
presence of increased levels of such smallRNAs. For example, RNAIII, SprD, SprC, RsaE, SprA1, SSR42, ArtR, SprX, and Teg49. Host neutrophils cause DNA...
conventional miRNA detection methods. miRNAs are a category of small, non-coding RNAs in the range of 18-25 base pairs in length. miRNAs regulate cellular...
non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic mechanism. Members of the RNase H family...
ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their...
reference trees were reconstructed using either the highly conserved small subunit ribosomal RNA sequences, a consensus of the available gene trees or concatenated...
interfacial ligands with various functional moieties (from small organic molecules to polymers to DNA to RNA) afford colloidal gold much of its vast functionality...
any biological complex of protein, RNA, DNA (sometimes has lipids and carbohydrates) Docking (molecular) – small molecule docking to proteins Levinthal...
translation into a protein. An mRNA produced in abundance may be degraded rapidly or translated inefficiently, resulting in a small amount of protein. as mentioned...
DLS instruments are for instance part of the quality control process for mRNA vaccines formulated in lipid nanoparticle carriers. There is a large number...
structure-based protein engineering; SAR and SPR visualization; ligand-based design; protein, DNA/RNA modeling; virtual screening; 3D pharmacophore screening;...
Kim, J; Song, C. W; Yoon, S (2016). "Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure...
On-Bead Ligand Binding assays are isolation methods for basic proteins, DNA/RNA or other biomolecules located in undefined suspensions and can be used in...
single cells, or DNA hybridization. The concept of classical SPR has been since 1968 but the SPR imaging technique was introduced in 1988 by Rothenhäusler...
While the purpose of the irradiation is to degrade the DNA/RNA of contaminating germs, a small proportion of the nutrient load is also degraded in the process...
display, ribosome display, yeast display or mRNA display. The artificial binding proteins are much smaller than antibodies (usually less than 100 amino-acid...
Andy Peng (2014). "Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos". Cell. 156 (4): 836–843. doi:10...
"Cloning and regulation of cornifin beta, a new member of the cornifin/spr family. Suppression by retinoic acid receptor-selective retinoids". J. Biol...
data are immediate and discretely defined - distinct nucleotides in DNA or RNA sequences and distinct amino acids in protein sequences. However, defining...
included for completeness. All 0–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z * on IATA code indicates a controlled duplicate. italics indicates a defunct...
"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8...
for the Human Papillomavirus, a common cause of cervical cancer. 2007 – RNA, long upstaged by its more glamorous sibling, DNA, is turning out to have...
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