Global InformationOptimer ligand information
Optimer ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their target molecules with affinity typically in the low nanomolar range.[1] Optimers can be used as antibody mimetics in a range of applications,[2][3][4] and have been optimized to increase their stability, reduce their molecular weight, and offer increased scalability and consistency in manufacture compared to standard aptamer molecules.[5]
- ^ "Monitoring-antibiotic-concentrations-with-rapid-Optimer™ based diagnostic assays". Aptamer Group. 10 March 2021. Retrieved 2021-07-30.
- ^ Maugi, R; Gamble, B; Bunka, D; Platt, M (2021). "A simple displacement aptamer assay on resistive pulse sensor for small molecule detection". Talanta. 225: 122068. doi:10.1016/j.talanta.2020.122068. PMID 33592786. S2CID 231945556. Retrieved 2021-06-01.
- ^ Sarell, CJ; Karamanos, TK; White, SJ; Barker, AM; Stockley, PG (2014). "Distinguishing Closely Related Amyloid Precursors Using an RNA Aptamer". Journal of Biological Chemistry. 289 (39): 26859–26871. doi:10.1074/jbc.M114.595066. PMC 4175327. PMID 25100729. Retrieved 2021-05-04.
- ^ Puscasu, A; Zanchetta, M; Posocco, B; Bunka, D; Stefano, T; Toffoli, G (2021). "Development and validation of a selective SPR aptasensor for the detection of anticancer drug irinotecan in human plasma samples". Analytical and Bioanalytical Chemistry. 413 (4): 1225–1236. doi:10.1007/s00216-020-03087-5. hdl:11368/3002248. PMID 33404749. S2CID 230782101.
- ^ "Accelerating rapid diagnostic development with Optimer™ reagents". YouTube. Aptamer Group. Retrieved 2021-08-09.