Splicing regulatory element (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome assembly. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene.[1]
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Wang, Zefeng; Christopher B. Burge (May 2008). "Splicing regulation: From a parts list of regulatory elements to an integrated splicing code". RNA. 14 (5): 802–813. doi:10.1261/rna.876308. ISSN 1355-8382. PMC 2327353. PMID 18369186.
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Splicingregulatoryelement (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general...
of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur...
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single...
protein biosynthesis (translation), RNA cleavage, RNA splicing, or transcriptional termination. Regulatory sequences are frequently associated with messenger...
inexcusable outcome in a healthcare setting Splicingregulatoryelement, a pre-mRNA element which regulates splicing acting in cis Serotonin reuptake enhancer...
An exonic splicing silencer (ESS) is a short region (usually 4-18 nucleotides) of an exon and is a cis-regulatoryelement. A set of 103 hexanucleotides...
separating the two fractions by gentle lysis. Alternative splicing can be analysed with a splicing array or with a tiling array (see DNA microarray). All...
important in splicing outcomes. They can be constructed to test the way both cis-regulatory elements (RNA effects) and trans-regulatory elements (associated...
which can cause aberrant splicing to occur. Aberrant splicing may also occur due to mutations within a splicingregulatoryelement. Intronic mutations that...
plays a regulatory role in alternative splicing. PTB's primary function is in exon silencing, by which a particular exon region normally spliced into the...
Transposable Element insertion in the Regulatory Region of the EO Gene in the Domesticated Silkworm", a TE insertion was observed in the cis-regulatory region...
thiazole moieties in bacteria. The THI element is an extension of a previously detected thiamin-regulatoryelement, the thi box, there is considerable variability...
An Alu element is a short stretch of DNA originally characterized by the action of the Arthrobacter luteus (Alu) restriction endonuclease. Alu elements...
lariat sequence to aid its splicing function. The small nuclear U2 RNA found in splicing complexes is thought to aid splicing by interacting with the lariat...
regulating the pre-mRNA splicing process CCNL2 NM_030937 Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates...
located close to a small intron that is spliced in males, but kept in females through splicing inhibition. This splicing inhibition is maintained by Sxl. When...
B. (2007). "RNA Structure Modulates Splicing Efficiency at the Human Immunodeficiency Virus Type 1 Major Splice Donor". Journal of Virology. 82 (6):...
response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs...
complex regulatory network capable of fine-tuning gene expression across the eukaryotic genome. The RNA coded by the short-interspersed nuclear element does...
location. The operator sequence next to the promoter is the main regulatoryelement in prokaryotes. Repressor proteins bound to the operator sequence...
gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (PKM1 contains exon 9 while PKM2 contains exon 10)...
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