RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
cytoplasm
transcription regulator complex
nucleus
nucleoplasm
cytosol
Biological process
regulation of transcription, DNA-templated
rhythmic process
positive regulation of DNA repair
negative regulation of cell death
circadian regulation of gene expression
transcription, DNA-templated
cellular response to DNA damage stimulus
response to redox state
positive regulation of transcription, DNA-templated
central nervous system development
circadian rhythm
regulation of response to DNA damage stimulus
positive regulation of transcription by RNA polymerase II
regulation of lipid metabolic process
positive regulation of behavioral fear response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4862
18143
Ensembl
ENSG00000170485
ENSMUSG00000026077
UniProt
Q99743
P97460
RefSeq (mRNA)
NM_002518
NM_008719
RefSeq (protein)
NP_002509
NP_032745
Location (UCSC)
Chr 2: 100.82 – 101 Mb
Chr 1: 39.23 – 39.4 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Neuronal PAS domain protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in humans is encoded by the NPAS2 gene.[5][6] NPAS2 is paralogous to CLOCK, and both are key proteins involved in the maintenance of circadian rhythms in mammals.[7] In the brain, NPAS2 functions as a generator and maintainer of mammalian circadian rhythms. More specifically, NPAS2 is an activator of transcription and translation of core clock and clock-controlled genes through its role in a negative feedback loop in the suprachiasmatic nucleus (SCN), the brain region responsible for the control of circadian rhythms.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000170485 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026077 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (January 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proceedings of the National Academy of Sciences of the United States of America. 94 (2): 713–8. Bibcode:1997PNAS...94..713Z. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.
^Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (March 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". The Journal of Biological Chemistry. 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689. S2CID 14908247.
^DeBruyne JP, Weaver DR, Reppert SM (May 2007). "CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock". Nature Neuroscience. 10 (5): 543–5. doi:10.1038/nn1884. PMC 2782643. PMID 17417633.
^Cite error: The named reference pmid19147932 was invoked but never defined (see the help page).
protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in humans is encoded by the NPAS2 gene. NPAS2 is paralogous...
Inferred motif from similar protein – In vivo/Misc source [629] VVNGCACGTMBNS NPAS2 ENSG00000170485 bHLH Known motif – High-throughput in vitro [630] DMCACGTGY...
solution. Three neptunium arsenide compounds have been prepared, NpAs, NpAs2, and Np3As4. The first two were first produced by heating arsenic and neptunium...
domain containing protein 2 (NPAS2, a CLOCK paralog) can substitute for CLOCK in these Clock-null mice. Mice with one NPAS2 allele showed shorter periods...
gene copy. The protein product of the gene interacts with both CLOCK and NPAS2 to bind to E-box sequences in regulated promoters and activate their transcription...
chaperonins and other small molecules like dioxin, but PAS B domains in NPAS2, a homolog of the Drosophila clk gene, and the hypoxia inducible factor...
Global Information
