The human papilloma virus E7 oncoprotein mimic of the LxCxE motif (red) bound to the host retinoblastoma protein (dark grey) (PDB: 1gux)
In molecular biology short linear motifs (SLiMs), linear motifs or minimotifs are short stretches of protein sequence that mediate protein–protein interaction.[1][2]
The first definition was given by Tim Hunt:[3]
"The sequences of many proteins contain short, conserved motifs that are involved in recognition and targeting activities, often separate from other functional properties of the molecule in which they occur. These motifs are linear, in the sense that three-dimensional organization is not required to bring distant segments of the molecule together to make the recognizable unit. The conservation of these motifs varies: some are highly conserved while others, for example, allow substitutions that retain only a certain pattern of charge across the motif."
^Diella F, Haslam N, Chica C, Budd A, Michael S, Brown NP, et al. (May 2008). "Understanding eukaryotic linear motifs and their role in cell signaling and regulation". Frontiers in Bioscience. 13 (13): 6580–603. doi:10.2741/3175. PMID 18508681.
^Neduva V, Russell RB (October 2006). "Peptides mediating interaction networks: new leads at last". Current Opinion in Biotechnology. 17 (5): 465–71. doi:10.1016/j.copbio.2006.08.002. PMID 16962311.
^Dice JF (August 1990). "Peptide sequences that target cytosolic proteins for lysosomal proteolysis". Trends in Biochemical Sciences. 15 (8): 305–9. doi:10.1016/0968-0004(90)90019-8. PMID 2204156.
and 26 Related for: Short linear motif information
In molecular biology shortlinearmotifs (SLiMs), linearmotifs or minimotifs are short stretches of protein sequence that mediate protein–protein interaction...
amino acids in a protein Shortlinearmotif, a stretch of protein sequence that mediates protein–protein interaction Structural motif, a pattern in a protein...
(EMBL)) for investigating shortlinearmotifs (SLiMs) in eukaryotic proteins. It is currently the largest collection of linearmotif classes with annotated...
Structures for Lossless Ion Manipulations, a form of ion optics SLiM, shortlinearmotif SLIM, slang for an amateur radio operator using a callsign without...
domains of FKBP25 is important for the binding of FKBP25 with DNA. Linearmotifs are short disordered segments of proteins that mediate functional interactions...
complex to be exported from the nucleus. Eukaryotic LinearMotif resource defines the NES motif for exportin within a single entry, TRG_NES_CRM1_1. The...
protein import". J. Biol. Chem. 280 (3): 1921–30. doi:10.1074/jbc.M403632200. PMID 15536088. Eukaryotic LinearMotif resource motif class TRG_PTS1 v t e...
RVxP motif is a protein motif involved in localizing proteins into cilia. Cilia are sensory organelle of cells, whose malfunction can cause diseases such...
A FFAT motif (FFAT being an acronym for two phenylalanines (FF) in an acidic tract) is a protein sequence motif of six defined amino acids plus neighbouring...
[ˈlaɪtmoˌtiːf]), literally meaning "leading motif", or "guiding motif". A musical motif has been defined as a "short musical idea ... melodic, harmonic, or...
Motif (stylized in all-uppercase MOTIF) is a series of music workstation synthesizers, first released by Yamaha Corporation in August 2001. The Motif...
least one protein. Minimotifs are also called sequence motifs or short linearmotifs or SLiMs. These are generally restricted to one secondary structure...
composed of BUB3, which binds to Mad3 and BUB1B through the shortlinearmotif known as the GLEBS motif. The exact order of attachments which must take place...
motifs or short melodic fragments, such as the opening of Beethoven's Fifth Symphony. Richard Wagner popularized the concept of a leitmotif: a motif or...
interact with PDCD6. The V domain of PDCD6IP recognises Shortlinearmotif LYPxLxxL and this motif is mimicked by p6 late domain of HIV and related viruses...
cargo destined for degradation to the lysosomes. TSG101 recognises shortlinearmotif : P(T/S)AP via the UEV protein domain of the VPS23/TSG101 subunit...
Altman carried the nonlinear motif in his films, including McCabe & Mrs. Miller (1971), Nashville (1975), The Player (1992), Short Cuts (1993), and Gosford...
shortlinearmotifs, protein–protein interactions and biological sequence alignment. His laboratory developed and hosts the Eukaryotic LinearMotif (ELM)...
Wang Y, Li Y, Chen Z (October 2008). "The conservation pattern of shortlinearmotifs is highly correlated with the function of interacting protein domains"...
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