Mice used in the research of human disease like AIDS
Mice with severe combined immunodeficiency (SCIDs) are often used in the research of human disease. Human immune cells are used to develop human lymphoid organs within these immunodeficient mice, and many different types of SCID mouse models have been developed. These mice allow researchers to study the human immune system and human disease in a small animal model.[1]
^Owen, Judith; Punt, Jenni; Stranford, Sharon (2013). Kuby Immunology. New York: W.H. Freeman and Company.
and 18 Related for: Severe combined immunodeficient mice information
lymphoid organs within these immunodeficientmice, and many different types of SCID mouse models have been developed. These mice allow researchers to study...
"Reconstitution of human haematopoiesis in non-obese diabetic/severecombinedimmunodeficientmice by clonal cells expanded from single CD34+CD38- cells expressing...
the development humanized mouse models. Nude mice were the earliest immunodeficient mouse model. These mice primarily produced IgM and had minimal or no...
mutation adversely affecting their inner ears Immunodeficient nude mice, lacking hair and a thymus: these mice do not produce T lymphocytes; therefore, they...
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain...
of immunodeficientmice can be used to establish PDX models: athymic nude mice, severely compromised immune deficient (SCID) mice, NOD-SCID mice, and...
A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severelyimmunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA)...
Brain The specific immunodeficientmice that were used were the NOD/SCID mouse (non-obese diabetic/severe conditional immunodeficient). These mutations...
"Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficientmice". Infect. Immun. 65 (10): 4165–72. doi:10.1128/IAI.65.10.4165-4172...
infection. The best treatment approach is to improve the immune status in immunodeficient individuals using highly active antiretroviral therapy that includes...
downregulated after differentiation. Teratoma formation: iPSCs injected into immunodeficientmice spontaneously formed teratomas after nine weeks. Teratomas are tumors...
the 1980s, particularly for dermatological studies. A hairless and immunodeficient breed was the result of a spontaneous genetic mutation in inbred laboratory...
activity. Unlike ES and iPS cells, transplanted Muse cells in testes of immunodeficientmice -a commonly used experiment to test the tumorigenicity of stem cells-...
crossing of a prkdc-/- and a IL2rga-/- strain that produced transparent, immunodeficient offspring, lacking natural killer cells as well as B- and T-cells....
Global Information