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NOG mouse information


A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA) in 2000. The NOG mouse accepts heterologous cells much more easily compared with any other type of immunodeficient rodent models, such as nude mouse and NOD/scid mouse. Thus, the mouse can be the best model as a highly efficient recipient of human cells to engraft, proliferate and differentiate.[1] This unique feature offers a great opportunity for enhancing therapy researches of cancer, leukemia, visceral diseases, AIDS, and other human diseases. It also provides applications for cancer, infection, regeneration, and hematology researches.

  1. ^ M. Ito and, et al. (2002). "NOD/SCID/γnull mouse: an excellent recipient mouse model for engraftment of human cells". Blood. 100 (9): 3175–3182. doi:10.1182/blood-2001-12-0207. PMID 12384415.

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NOG mouse

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A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA)...

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Humanized mouse

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Central Institute for Experimental Animals

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Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse, NOG mouse) and development of its applications...

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popular children's television programmes. Bagpuss, Pingwings, Noggin the Nog, Ivor the Engine, Clangers and Pogles' Wood, were all made by Smallfilms...

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Clangers

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of different ethnic groups were analyzed and made publicly available. EggNOG Database: a hierarchical, functionally and phylogenetically annotated orthology...

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created and produced Alexander the Mouse (1957–1958, lost), Ivor the Engine (1959, 1975–1977) and Noggin the Nog (1959–1965, 1982). Their initial animation...

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