Serine hydroxymethyltransferase 1 (cytosolic), homotetramer, Human
Identifiers
EC no.
2.1.2.1
CAS no.
9029-83-8
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BRENDA entry
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KEGG entry
MetaCyc
metabolic pathway
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PDB structures
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proteins
PyMol rendered crystal structure of serine hydroxymethyltransferase
Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an important role in cellular one-carbon pathways by catalyzing the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-methylenetetrahydrofolate (5,10-CH2-THF).[1] This reaction provides the largest part of the one-carbon units available to the cell.[2]
^Appaji Rao N, Ambili M, Jala VR, Subramanya HS, Savithri HS (April 2003). "Structure-function relationship in serine hydroxymethyltransferase". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1647 (1–2): 24–29. doi:10.1016/s1570-9639(03)00043-8. PMID 12686103.
^Stover P, Schirch V (August 1990). "Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate". The Journal of Biological Chemistry. 265 (24): 14227–14233. doi:10.1016/S0021-9258(18)77290-6. PMID 2201683.
and 25 Related for: Serine hydroxymethyltransferase information
Serinehydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an important role in cellular...
biosynthesis: Serinehydroxymethyltransferase (SHMT = serine transhydroxymethylase) also catalyzes the reversible conversions of L-serine to glycine (retro-aldol...
available concentration of serine in the cell. Glycine is biosynthesized from serine, catalyzed by serinehydroxymethyltransferase (SHMT). The enzyme effectively...
Serinehydroxymethyltransferase 2 is an enzyme that in humans is encoded by the SHMT2 gene. GRCh38: Ensembl release 89: ENSG00000182199 – Ensembl, May...
methotrexate. It is converted into 5,10-methylenetetrahydrofolate by serinehydroxymethyltransferase. Many bacteria use dihydropteroate synthetase to produce dihydropteroate...
action of serinehydroxymethyltransferase (SHMT) to yield 5,10-methylenetetrahydrofolate (5,10-CH2-THF). This reaction also consumes serine and pyridoxal...
the amino acid serine, which is in turn derived from 3-phosphoglycerate. In most organisms, the enzyme serinehydroxymethyltransferase catalyses this...
converts serine synthesized from the intermediates of glycolysis to glycine. In the glycolytic pathway, the enzyme serinehydroxymethyltransferase catalyzes...
two conserved signature indels (in the RpoC protein and in serinehydroxymethyltransferase) and one signature protein PG00081 have been identified that...
When coupled to serinehydroxymethyltransferase, the glycine cleavage system overall reaction becomes: 2 glycine + NAD+ + H2O → serine + CO2 + NH3 + NADH...
also be tightly controlled to avoid self-poisoning. Serinehydroxymethyltransferase can decompose serine into formaldehyde and glycine, according to this...
methylene-THF and ammonia. Methylene-THF is then used by serinehydroxymethyltransferase to synthesize serine from glycine. This system is part of plant photorespiration...
GTP-binding elongation factors, Methionine aminopeptidase 2, Serinehydroxymethyltransferase, and ATP transporters. Components of the transcription machinery...
activity has been demonstrated in both L-threonine aldolase and serinehydroxymethyltransferase, although whether this is the main catalytic activity of these...
SHMT may refer to: Serinehydroxymethyltransferase, an enzyme Simultaneous and heterogeneous multithreading, in computing Shah Murtaza Halt railway station...
ribonucleotide reductase. It may also inhibit transcription of serinehydroxymethyltransferase, which has zinc dependence. In cell culture, serum is the growth...
photorespiratory reactions are preferentially catalyzed by glutamate:glyoxylate and serine:glyoxylate aminotransferases in rice". Journal of Photochemistry and Photobiology...
bacterium Pseudomonas fluorescens. Obafluorin is a inhibitor of serinehydroxymethyltransferase. Scott, Thomas A.; Batey, Sibyl F.; Wiencek, Patrick; Chandra...
encoding protein Serine (or cysteine) peptidase inhibitor, clade A, member 3F SHMT2: encoding protein Serinehydroxymethyltransferase 2 SLC8B1: solute...
two conserved signature indels (in the RpoC protein and in serinehydroxymethyltransferase) and one signature protein PG00081 have been identified that...
using a mixture of three biosynthetic pathways, which are the serinehydroxymethyltransferase pathway, the threonine aldolase pathways, and the reverse of...
insert in the RpoC protein and a 13-16 amino acid insertion in serinehydroxymethyltransferase) and one signature protein (PG00081) that are uniquely shared...
inhibitor with an IC50 of 35 nM was designed. Mitochondrial serinehydroxymethyltransferase (SHMT) inhibitors were also found. Three hundred thousand compounds...
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