The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.[citation needed]
Drawn from international guidelines that emerged from the Surviving Sepsis Campaign[1][2] the Sepsis Six was developed by The UK Sepsis Trust.[3] (Daniels, Nutbeam, Laver) in 2006 as a practical tool to help healthcare professionals deliver the basics of care rapidly and reliably.
In 2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was associated with a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days.[4] Though the authors urge caution in a causal interpretation of these findings.[citation needed]
The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis:[citation needed]
Titrate oxygen to a saturation target of 94%
Take blood cultures and consider source control
Administer empiric intravenous antibiotics
Measure serial serum lactates
Start intravenous fluid resuscitation
Commence accurate urine output measurement.
^Cite error: The named reference :0 was invoked but never defined (see the help page).
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^Cite error: The named reference sepsistrust was invoked but never defined (see the help page).
^Cite error: The named reference :2 was invoked but never defined (see the help page).
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This...
The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional organizations in reducing mortality from sepsis. The purpose...
sequential organ failure assessment score (SOFA score), previously known as the sepsis-related organ failure assessment score, is used to track a person's status...
Sepsis Alliance is a non-profit organization dedicated to raising awareness of sepsis. This awareness is accomplished through a variety of methods, including...
to create the "Sepsis-Related Organ Failure Assessment (SOFA)" score to describe and quantitate the degree of organ dysfunction in six organ systems....
Sepsis cynipsea is a European species of fly and member of the family Sepsidae. It is a coprophagous fly that feeds on dung. These flies are most commonly...
of the amniotic sac) which substantially increases the risk of neonatal sepsis by allowing passage for bacteria to enter the womb prior to the birth of...
working as science research students in London. Linstead's mother died of sepsissix days after giving birth, and Linstead was raised by a nanny until the...
2012) was a dentist of Indian origin, living in Ireland, who died from sepsis after her request for an abortion was denied on legal grounds. In the wake...
vaccine-preventable. While best known as a cause of meningitis, it can also result in sepsis, which is an even more damaging and dangerous condition. Meningitis and...
blood pressure falls during the early stages of sepsis, causing a widening of pulse pressure. If sepsis becomes severe and hemodynamic compromise advances...
2-year-old daughter Maude died of sepsis. He dedicated his 2015 BAFTA award to her and campaigns for greater awareness of sepsis. He is a Patron of Child Bereavement...
narrows and lengths over a few weeks. Postpartum infections can lead to sepsis and if untreated, death. Postpartum urinary incontinence is experienced...
widespread, painful inflammation of the inner lining of the abdominal wall and sepsis. Appendicitis is primarily caused by a blockage of the hollow portion in...
the NBC series The Blacklist since the third season until his death from sepsis. He is replaced by actor Ron Raines during the show's eighth season. In...
tissue to get to infected sites. Plasma hyaluronic acid is elevated in sepsis and septic shock and correlate with disease severity, but the effect on...
bloodstream, a process known as translocation, with bacteremia leading to sepsis. The most common bacteria involved in severe cases are Clostridium, Campylobacter...
region of the β-chain of the T cell antigen receptor. "Sepsis and Toxic Shock Syndrome". Sepsis Alliance. 18 June 2024. Archived from the original on 24...
acute respiratory distress syndrome. (ALI-ARDS) cover many of these causes, Sepsis- Severe infection or inflammation which may be local or systemic. This is...
over to protect the body from damage. Sepsis also carries high antigen load and inflammation. In this stage of sepsis T cell exhaustion increases. Currently...
of pregnant women and prevention of 65–70% of cases of early onset GBS sepsis. This group includes S. equi, which causes strangles in horses, and S. zooepidemicus...
trust of the imposter, Beatrice, who dies after her infection turns into sepsis that fails to respond to treatment. Jared romantically pursues his burn-victim...
However, during a battle, he receives an injury that eventually develops into sepsis. In a desperate attempt to save his life, Daenerys asks one of their captured...
Assessment Committee (PRAC) warns about serious risks for bacteraemia and sepsis due to previous publications. PRAC stipulates marketing conditions for Bacillus...
Global Information