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Bovine seminal RNase (BS-RNase) is a member of the ribonuclease superfamily produced by the bovine seminal vesicles. This enzyme can not be differentiated from its members distinctly since there are more features that this enzyme shares with its family members than features that it possess alone. The research on the question of how new functions arrive in proteins in evolution led the scientists to find an uncommon consequence for a usual biological event called gene conversion in the case of the ribonuclease (RNase) protein family.[1] The most well-known member of this family, RNase A (also called pancreatic RNase), is expressed in the pancreas of oxen. It serves to digest RNA in intestine, and evolved from bacteria fermenting in the stomach of the first ox.[2] The homologous RNase, called seminal RNase, differs from RNase A by 23 amino acids and is expressed in seminal plasma in the concentration of 1-1.5 mg/ml, which constitutes more than 3% of the fluid protein content.[3] Bovine seminal ribonuclease (BS-RNase) is a homologue of RNase A with specific antitumor activity.
^Beintema, J.J; Schuller, C., Irie, M. and Carsana, A. (1988). "Molecular evolution of the ribonuclease superfamily". Prog. Biophys. 51 (3): 165–192. doi:10.1016/0079-6107(88)90001-6. PMID 3074337.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Barnard, E.A (1969). "Biological Function of Pancreatic Ribonuclease". Nature. 221 (5178): 340–344. Bibcode:1969Natur.221..340B. doi:10.1038/221340a0. PMID 4974403. S2CID 4240282.
^D'Alessio, G. (1962). "Isolation of seminal RNase". Biochem. J. 7.
Bovine seminalRNase (BS-RNase) is a member of the ribonuclease superfamily produced by the bovine seminal vesicles. This enzyme can not be differentiated...
Pancreatic ribonuclease family (EC 4.6.1.18, RNase, RNase I, RNase A, pancreatic RNase, ribonuclease I, endoribonuclease I, ribonucleic phosphatase, alkaline...
genome, milk RNase inhibits reverse transcription of retroviruses that cause breast cancer in mice. Parsi women in West India have the milk RNase level markedly...
but allosterically activate the IRE1α RNase domain. Compound 3 prevents kinase activity, oligomerization and RNase activity. Apart from its function as...
Blackford JA, Judge CS, Liu M, Xiao W, Kalvakolanu DV, Hassel BA (March 2000). "RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the...
with Alan Fersht resulted in the seminal application of phi-value analysis to the study of barnase, a bacterial RNAse used in many protein folding studies...
Ralph Hirschmann 2002 "For the first synthesis of an enzyme in solution (RNase); the concept of stereolectronic control; the use of prodrugs to reduce...
C, Dougherty JP, Peltz SW (Jun 2005). "A newly discovered function for RNase L in regulating translation termination". Nature Structural & Molecular...
available at low cost to scientists around the world. This generous act made RNase A the main protein for basic research for the next few decades, resulting...
PMID 10024167. Jiang T, Altman S (Apr 2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease...
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