The University of Texas at Austin (2012-present) Northwestern University (1996-2012) University of Basel (1993-1996) University of Cambridge (1988-1993)
Doctoral advisor
Sir Alan Fersht
Website
www.matouscheklab.org
Andreas Matouschek is a biochemist at The University of Texas at Austin, where he is a professor in the College of Natural Sciences.[1] His graduate work with Alan Fersht resulted in the seminal application of phi-value analysis to the study of barnase, a bacterial RNAse used in many protein folding studies.[2] Development of phi value analysis in combination with extensive protein engineering enabled an understanding of the kinetic intermediates during protein folding of barnase. In subsequent postdoctoral work at the University of Basel, he studied how mitochondria refold proteins after importing them. In 1996, he moved to Northwestern University. In 2012, he moved to The University of Texas at Austin.
Matouschek currently studies the proteasome, the degradation machinery of eukaryotic cells, and the mechanisms by which the proteasome is able to unfold and translocate proteins.[3]
^"Matouschek, Andreas (CNS Faculty Profiles)". The University of Texas at Austin.
^Matouschek, Andreas; Kellis, James T.; Serrano, Luis; Bycroft, Mark; Fersht, Alan R. (1990). "Transient folding intermediates characterized by protein engineering". Nature. 346 (6283): 440–5. Bibcode:1990Natur.346..440M. doi:10.1038/346440a0. PMID 2377205. S2CID 4316156.
^Schrader, Erin K; Harstad, Kristine G; Matouschek, Andreas (2009). "Targeting proteins for degradation". Nature Chemical Biology. 5 (11): 815–22. doi:10.1038/nchembio.250. PMC 4228941. PMID 19841631.
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