USP18 information

USP18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CHT, 5CHV
Identifiers
Aliases	USP18, ISG43, UBP43, ubiquitin specific peptidase 18, PTORCH2
External IDs	OMIM: 607057; MGI: 1344364; HomoloGene: 8047; GeneCards: USP18; OMA:USP18 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	18,177,397 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	121,247,876 bp
RNA expression pattern
	Top expressed in
	gonad; ; left testis; ; right testis; ; testicle; ; subcutaneous adipose tissue; ; liver; ; lymph node; ; right lobe of liver; ; islet of Langerhans; ; placenta;
	Top expressed in
	mucous cell of stomach; ; transitional epithelium of urinary bladder; ; decidua; ; thymus; ; seminal vesicula; ; granulocyte; ; submandibular gland; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; protein binding; hydrolase activity; thiol-dependent deubiquitinase; ISG15-specific protease activity; cysteine-type endopeptidase activity;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	regulation of type I interferon-mediated signaling pathway; ubiquitin-dependent protein catabolic process; proteolysis; protein deubiquitination; regulation of inflammatory response; regulation of protein stability;
	Sources:Amigo / QuickGO
Orthologs
	11274
	24110
	ENSG00000184979
	ENSMUSG00000030107
	Q9UMW8
	Q9WTV6
	NM_017414
	NM_011909
	NP_059110
	NP_036039
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is a type I interferon receptor repressor and an isopeptidase. In humans, it is encoded by the USP18 gene.^[5] USP18 is induced by the immune response to type I and III interferons, and serves as a negative regulator of type I interferon, but not type III interferon. Loss of USP18 results in increased responsiveness to type I interferons and life-threatening autoinflammatory disease in humans due to the negative regulatory function of USP18 in interferon signal transduction. Independent of this activity, USP18 is also a member of the deubiquitinating protease family of enzymes. It is known to remove ISG15 conjugates from a broad range of protein substrates, a process known as deISGylation.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184979 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030107 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: USP18 ubiquitin specific peptidase 18".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184979 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030107 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: USP18 ubiquitin specific peptidase 18".

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