"SIgAD" redirects here. For the signals intelligence activity, see SIGAD.
Medical condition
Selective immunoglobulin A deficiency
The dimeric IgA molecule. 1 H-chain, 2 L-chain, 3 J-chain, 4 secretory component
Specialty
Immunology
Selective immunoglobulin A (IgA) deficiency (SIgAD[1]) is a kind of immunodeficiency, a type of hypogammaglobulinemia. People with this deficiency lack immunoglobulin A (IgA), a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. It is defined as an undetectable serum IgA level in the presence of normal serum levels of IgG and IgM, in persons older than 4 years. It is the most common of the primary antibody deficiencies. Most such persons remain healthy throughout their lives and are never diagnosed.
^Hammarström L, Vorechovsky I, Webster D (May 2000). "Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)". Clinical and Experimental Immunology. 120 (2): 225–231. doi:10.1046/j.1365-2249.2000.01131.x. PMC 1905641. PMID 10792368.
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SelectiveimmunoglobulinA (IgA) deficiency (SIgAD) is a kind of immunodeficiency, a type of hypogammaglobulinemia. People with this deficiency lack immunoglobulin...
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plasma cells. The most common such immunodeficiency is inherited selective IgA deficiency, occurring between 1 in 100 and 1 in 1000 persons, depending on...
is a reduction in all types of gamma globulins. There are four main types of dysgammaglobulinemia. SelectiveimmunoglobulinAdeficiency - Selective immunoglobulin...
ImmunoglobulinA (Ig A, also referred to as sIgA in its secretory form) is an antibody that plays a role in the immune function of mucous membranes. The...
IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes...
deficiency, IgA with IgG subclass deficiency, selective immunoglobulinAdeficiency Specific antibody deficiency to specific antigens with normal B cell and normal...
who have not received a formal diagnosis. Milder forms of primary immunodeficiency, such as selectiveimmunoglobulinAdeficiency, are fairly common, with...
An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form...
IgA anti-plasma protein antibodies. For patients who have selectiveimmunoglobulinAdeficiency, the reaction is presumed to be caused by IgA antibodies...
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complex can lead to bare lymphocyte syndrome (BLS), which is a type of MHC class II deficiency. Like MHC class I molecules, class II molecules are also heterodimers...
caused by a false lab measurement of sodium due to massive increases in blood triglyceride levels or extreme elevation of immunoglobulins as may occur...
c-myc, an oncogene encoding a transcription factor, is translocated to a position after the promoter of the immunoglobulin gene, leading to dysregulation...
deficiency. However, the concurrent treatment of ADA injections may impair the success of gene therapy, since transduced cells will have no selective...
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hemoglobin deficiency.[citation needed] Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying...
immunoglobulins. IgA from plasma cells in the mucosa are absorbed through receptor-mediated endocytosis on the basolateral surface and released as a receptor-IgA...
immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); and the physical, chemical, and physiological...
transmembrane glycoprotein in the immunoglobulin superfamily (IgSF) with two extracellular C2-set Ig-like domains and a relatively large, 240 amino acid...
is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and...
leukemia, clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for...
in cases of deficiency and excess. Deficiency of vitamin B12 causes subacute combined degeneration, a disease classically associated with a central demyelinating...
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